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Journal of Personalized Medicine, Volume 14, Issue 3

2024 March - 110 articles

Cover Story: Sepsis is one of the most common causes of morbidity and mortality worldwide. Despite the remarkable advances in modern medicine throughout the last century, the mortality rates associated with sepsis have remained significantly elevated, both in high- and low-income countries. The main difficulty in the diagnosis and treatment of septic patients is the tremendous heterogeneity of this condition. The vast heterogeneity that characterizes sepsis ranges from its clinical presentation to the biological aspects of the disease. Evidence-based medicine approaches sepsis as a homogenous syndrome and does not consider the individual discrepancies between septic patients. This approach may contribute to the poor outcomes of such patients. In recent years, personalized medicine has gained significant interest. View this paper
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Articles (110)

  • Article
  • Open Access
1 Citations
2,656 Views
10 Pages

Association between Gout and Gastric Cancer: A Nested Case–Control Study Using a National Health Sample Cohort

  • Mi Jung Kwon,
  • Kyeong Min Han,
  • Ji Hee Kim,
  • Joo-Hee Kim,
  • Min-Jeong Kim,
  • Nan Young Kim,
  • Hyo Geun Choi and
  • Ho Suk Kang

21 February 2024

Given the global significance of gout and gastric cancer (GC) as major health problems with interrelated impacts, we examined the development of GC in Korean patients with gout. We conducted a nested case–control study using data from 10,174 GC...

  • Article
  • Open Access
1 Citations
2,347 Views
11 Pages

Associations between Verbal Fluency and Asymmetry of White Matter Integrity in the Superior Longitudinal Fasciculus in At-Risk Mental States for Psychosis

  • Junichi Saito,
  • Naoyuki Katagiri,
  • Hiromi Tagata,
  • Yu Arai,
  • Kouhei Kamiya,
  • Masaaki Hori,
  • Masafumi Mizuno and
  • Takahiro Nemoto

21 February 2024

Verbal fluency is one of the most severely impaired components of cognitive function in schizophrenia and is also impaired in at-risk mental states (ARMSs) for psychosis. The aim of this study was to explore the markers of disease progression in subj...

  • Article
  • Open Access
5 Citations
6,276 Views
12 Pages

Diagnostic Accuracy of Fecal Calprotectin in Discriminating Organic-Inflammatory Gastrointestinal Diseases and Functional Gastrointestinal Disorders in Older Patients

  • Antonella Gallo,
  • Marcello Covino,
  • Silvia Baroni,
  • Sara Camilli,
  • Francesca Ibba,
  • Silvia Andaloro,
  • Maria Chiara Agnitelli,
  • Fiammetta Maria Rognoni,
  • Francesco Landi and
  • Massimo Montalto

21 February 2024

Fecal calprotectin (FC) has been largely recognized as a surrogate marker of intestinal neutrophilic inflammation, very reliable in distinguishing between inflammatory bowel diseases and functional gastrointestinal (GI) disorders. Aging has been sugg...

  • Article
  • Open Access
8 Citations
7,836 Views
10 Pages

Iatrogenic Cerebrospinal Fluid Leak in Endoscopic Sinus Surgery: Topographical Map and Influence of Skull Base Asymmetry

  • Alessandro Vinciguerra,
  • Isabelle Dohin,
  • Antonio Daloiso,
  • Francesco Boaria,
  • Morgane Marc,
  • Benjamin Verillaud,
  • Florian Chatelet and
  • Philippe Herman

21 February 2024

Background: Iatrogenic cerebrospinal fluid leak (iCSF-L) is a major complication of endonasal surgeries whose occurrence is always a potential adverse event due to anatomical variation/asymmetry of the skull base (SB). The aim of this manuscript is t...

  • Review
  • Open Access
8 Citations
6,650 Views
18 Pages

The Omics Complexity in Sepsis: The Limits of the Personalized Medicine Approach

  • Sebastian Isac,
  • Teodora Isac,
  • Maria Daniela Tanasescu,
  • Bogdan Pavel,
  • Cristina Veronica Andreescu,
  • Andrada-Georgiana Badea,
  • Damiana Ojog,
  • Geani-Danut Teodorescu,
  • Anca Laceanu and
  • Gabriela Droc
  • + 1 author

20 February 2024

Sepsis is one of the most common causes of morbidity and mortality worldwide. Despite the remarkable advances in modern medicine throughout the last century, the mortality rates associated with sepsis have remained significantly elevated, both in hig...

  • Article
  • Open Access
2,972 Views
22 Pages

20 February 2024

Gastrointestinal (GI) cancers are some of the main public health threats to the world. Even though surgery, chemotherapy, and targeted therapy are available for their treatments, these approaches provide limited success in reducing mortality, making...

  • Article
  • Open Access
3 Citations
2,606 Views
13 Pages

Open Retrograde Stenting of Proximal Innominate and Common Carotid Artery Stenosis

  • Marvin Kapalla,
  • Albert Busch,
  • Steffen Wolk and
  • Christian Reeps

20 February 2024

Purpose: The evidence regarding the treatment of open retrograde stenting of innominate artery (IA) or common carotid artery stenosis (CCA) is limited, and is suspected to carry a high risk of stroke and death. Therefore, the objective of this study...

  • Article
  • Open Access
9 Citations
5,643 Views
11 Pages

Risk Factors for Recurrence of Primary Sclerosing Cholangitis after Liver Transplantation: Single-Center Data

  • Elisa Catanzaro,
  • Enrico Gringeri,
  • Nora Cazzagon,
  • Annarosa Floreani,
  • Umberto Cillo,
  • Patrizia Burra and
  • Martina Gambato

20 February 2024

Background: Primary sclerosing cholangitis (PSC), comprising 5–15% of European liver transplantation (LT) cases, poses a significant challenge due to the risk of post-transplant disease recurrence (rPSC). This single-center study aimed to deter...

  • Article
  • Open Access
8 Citations
2,995 Views
11 Pages

20 February 2024

Background: Multiple myeloma is a hematological malignancy characterized by anemia, antibodies causing kidney damage, and damage to multiple organs, which come together to cause morbidity. Although oxidative stress is not a core pathological aspect o...

  • Article
  • Open Access
3 Citations
4,734 Views
13 Pages

20 February 2024

Injuries to the articular cartilage of the human knee joint, commonly resulting from trauma, inflammation, or age- and activity-related wear and tear, have significant implications, primarily leading to osteoarthritis (OA). Conservative treatments fo...

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J. Pers. Med. - ISSN 2075-4426