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Background: Antibiotic-associated gut dysbiosis affects lung health and contributes to disease progression, but the individual response to antibiotics, which leads to host-specific reactions to the same respiratory insult, is not fully understood. Me...

Experimental evidence has shown that gallic acid (GA), a naturally occurring polyphenolic compound, and docetaxel (DTX), a taxane chemotherapeutic agent, each possess antitumor activity against multiple cancer types. Although both compounds have been...

Coastal saline–alkaline land has considerable potential for soil carbon sequestration, but how different land-use types affect microbial resource limitation and carbon-use efficiency (CUE) in coastal saline–alkaline soils remains unclear....

Marine macroalgae are now considered potential sources of renewable feedstocks to produce valuable bioactive compounds. However, the species-specific volatilomes and their correlation with antioxidant capacity remains largely unknown. This study aime...

The Consensus Molecular Subtype (CMS) classification provides a widely used transcriptomic framework for colorectal cancer (CRC) stratification with clear prognostic and therapeutic relevance. However, it does not fully capture the immune–metab...

Autoimmune diseases arise from a breakdown of immune tolerance and complex interplay of genetic susceptibility, environmental triggers, tissue-specific immune responses, microbiota, and regulatory pathways. Mouse models remain essential for dissectin...

In this study, we constructed a comparative genomic framework encompassing 57 genome sequences from four key taxonomic groups—Bacillariophyta, Parmales, choanoflagellates, and Bacillus—all of which possess either siliceous cell walls or s...

Semen quality is a key determinant of reproductive performance in breeding boars, and emerging evidence suggests the seminal microbiome may influence sperm function. However, the composition of the seminal plasma microbiome and its relationship to sp...

Environmental stressors such as heavy metals and pesticides pose significant threats to honeybee health by inducing oxidative stress. Enhancing nutritional supply has emerged as a potential strategy for honeybees to enhance stress resistance. However...

Dextran sodium sulfate (DSS) was used to induce ulcerative colitis in a porcine model to investigate the transcriptional responses in inflamed colonic tissue. Eleven pigs were divided into two groups, of which five pigs were administered an oral dose...

Phenylketonuria (PKU) is an autosomal recessive inborn error of phenylalanine (Phe) metabolism caused by pathogenic variants in the phenylalanine hydroxylase (PAH) gene, resulting in toxic phenylalanine accumulation that, if untreated, causes profoun...

Epstein–Barr virus (EBV) is a highly prevalent oncogenic virus that establishes persistent infection in most of the human population and is strongly associated with several lymphoid and epithelial malignancies, particularly nasopharyngeal carci...

Tetrabromobisphenol A mono(2-hydroxyethyl) ether (TBBPA-MHEE) is an important byproduct during the production of tetrabromobisphenol A (TBBPA) and its related derivatives. Although it has been detected in aquatic environments, its in vivo development...

The neuronal ceroid lipofuscinoses are the most common group of human paediatric genetic neurodegenerative disorders and have also been reported in multiple animal species. This study explores sheep with the CLN6 disease subtype, which occurs in huma...

Phytobiotics are promising dietary tools to improve metabolic stability and physiological resilience against chemical stressors in aquaculture. This study evaluated nrf2-linked antioxidant and metabolic modulation by dietary Origanum vulgare essentia...

Average nucleotide identity (ANI) values of 95–96% and digital DNA–DNA hybridization (dDDH) values of 70% are currently regarded as the gold standards for bacterial species delineation. However, the accuracy and applicability of ANI thres...

Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative disorders worldwide and is characterized by progressive memory impairment, cognitive decline, and behavioral dysfunction. The brain’s high energy demand makes it vuln...

Bacopa monnieri (Brahmi), a valuable medicinal herb, faces challenges in consistent production and quality under natural cultivation. To overcome these limitations, this study investigated the impact of different light qualities (warm-white, red, blu...

Obesity is a major global health problem and is closely associated with a broad range of metabolic disorders, including metabolic syndrome (MetS), dyslipidemia, hypertension, atherosclerosis, type 2 diabetes mellitus, and cardiovascular disease. The...

Background: Incorporating probiotic bacteria such as BC, a spore-forming probiotic bacterium known for its resistance, into extruded snacks has emerged as an innovative approach to developing functional foods. Little is known about how the addition i...

Pulmonary fibrosis (PF) is a progressive lung condition characterized by irreversible scarring and high mortality, with limited effective treatments. Mitochondrial dysfunction has emerged as a critical factor in fibroblast activation in PF, although...

Marine bivalves represent promising experimental models for the development of in vitro approaches in environmental biology, ecotoxicology, and bioactive compound screening. However, their application remains limited compared with that of more establ...

Factors regulating the genesis and expansion of basal progenitor cell sub-populations, including intermediate progenitor cells, are critical determinants of cortical neurogenesis and brain growth. Epigenetic (chromatin) marks have emerged as notable...

The size of the mitogenome varies greatly in angiosperms from different species, but the causes of expansion remain unclear. Species from the Zingiberaceae family often carry exceptionally large mitogenomes, where this phenomenon can be readily studi...

Inflammation is a critical protective response that maintains tissue homeostasis. However, persistent or dysregulated inflammation contributes significantly to the progression of cancer and neurodegenerative diseases. Recent advances in RNA biology h...

Cutaneous metastases are an uncommon but clinically significant manifestation of internal malignancy, occurring in approximately 0.7–10.4% of patients with cancer. In some cases, they represent the first clinical manifestation of an otherwise o...

Cynops orientalis, a member of the Salamandridae family, can regenerate severely injured limbs throughout its lifespan. The molecular mechanisms regulating limb regeneration in C. orientalis remain largely unknown. SERCA1 (sarcoplasmic/endoplasmic re...

During mitosis sister chromatids are accurately segregated into two daughter cells through a microtubule-based structure known as the mitotic spindle. Errors in mitotic spindle formation have been associated with human diseases and tumorigenesis. Chk...

Chronic obstructive pulmonary disease (COPD) represents a major global health issue, characterized by persistent airflow limitation, chronic inflammation, and progressive tissue remodeling. Its clinical and molecular heterogeneity, combined with the...

Epimedium sagittatum is an important understory shade-tolerant medicinal plant native to China. However, assessments of its responses to climate change under multiple scenarios and time periods remain insufficient, particularly regarding the mitigati...

Anthocyanins dictate the nutritional quality of purple-fleshed sweetpotato (PFSP), yet how the lignin pathway influences anthocyanin biosynthesis and phenylpropanoid metabolic flux allocation remains largely elusive. Through integrated transcriptomic...

Current approaches for preventing and suppressing the initiation and development of keratinocyte carcinoma remain limited, highlighting the urgent need to identify novel targets for tumor intervention. As major environmental pathogenic factor, chroni...

Ganoderma lucidum (Lingzhi or Reishi) is among the most extensively studied medicinal mushrooms globally, owing to its diverse bioactive compounds and broad pharmacological properties. A scientometric analysis using the Scopus database was conducted...

Ehlers–Danlos syndromes (EDSs) are heritable connective tissue disorders caused by defects in collagen and related extracellular matrix proteins. Because the vocal fold (VF) lamina propria is a collagen-dependent structure, the voice might be e...

Vitamin B6 is a coenzyme involved in more than 150 biochemical reactions in the body. Its intake has favorable effects for many diseases like Parkinson’s disease, glaucoma, and endometriosis. Vitamin B6 can be obtained from tablets, aqua vitami...

Spatially resolved single-cell technologies can provide deep insights into cellular heterogeneity and tissue structural characteristics. However, the data obtained are purely observational and cannot reveal the specific mechanisms by which tissues re...

Bats (order Chiroptera) are among the most diverse and ecologically vital mammals, defined by powered flight, remarkable echolocation, and exceptional physiological adaptations [...]

Bee pollination enhances the yield and fruit quality of loquats (Eriobotrya japonica Lindl.). However, the systemic effects of pollination on fruit metabolomics, particularly the metabolic differences among various cultivars following pollination, re...

Background: Glycemic control influences a wide range of psychiatric and physiological symptoms. Many psychiatric conditions are linked to poor glucose regulation. Anti-nuclear antibodies (ANAs), widely used to screen for autoimmune disease, may somet...

We present the first vascular flora of Sirente-Velino Regional Park, a protected area located in central Apennine (Abruzzo, Central Italy), covering 550 km². The floristic inventory was compiled based on extensive field surveys conducted from 1990 to...

Microphysiological Systems (MPS) have emerged as a transformative platform in biomedical research, enabling the investigation of disease mechanisms, drug screening, and toxicity prediction by closely simulating human physiological functions. However,...

Structural atrophy and metabolic dysfunction provide complementary biomarkers for Alzheimer’s disease (AD), and their joint modeling may support diagnostic assessment and cognitive score estimation. However, many multimodal methods rely on glob...

Tyrannosaurs were giant predatory dinosaurs that occupied the apex of Late Cretaceous food chains. Little is known about the early life and reproductive ecology of tyrannosaurs due to the extreme rarity of hatchling and juvenile fossils. We report bo...

CRISPR-associated protein 9 (Cas9)-mediated editing generates numerous mutations. Existing detection methods, such as ACT-PCR, T7EI endonuclease cleavage, HRM analysis, and high-throughput sequencing, often require stringent conditions, expensive rea...

Alternative splicing (AS) increases transcriptomic diversity; however, its role in teleost larval nutritional physiology remains undetermined. This study investigated alternative splicing (AS) dynamics associated with nutritional transition and the s...

Feline panleukopenia virus (FPV) causes severe enteric and systemic disease in cats, with particular importance in shelter environments where susceptible kittens, high population turnover, environmental contamination, and variable vaccination histori...

Açaí is considered a super fruit for its high concentration of flavonoid polyphenols, predominantly anthocyanins. The nutraceutical effect of açaí as an anti-inflammatory and antiapoptotic agent has been reported. This stu...

Background: Su(var)3-9 SET genes encode key histone methyltransferases that catalyze H3K9 methylation, a modification generally associated with heterochromatin formation and transcriptional repression. Methods: We identified 23 GmSu(var)3-9 SETs and...

The COBRA gene family is crucial for plant cell wall formation and stress adaptation. Although COBRA/COBL genes have been characterized in several plant species, their potential contribution to cell wall-mediated responses in woody plants under combi...

Myotonic dystrophy type 1 (DM1) is caused by an expansion of CTG repeats in the DMPK gene. In a proportion of patients, the expanded allele contains variant repeats, which have been associated with later disease onset and different clinical presentat...