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Reactive oxygen species (ROS) are critical drivers of redox-associated biogeochemical processes within the rhizosphere, yet the mechanisms of their generation under contaminant stress remain poorly understood. A 24-day pot cultivation experiment with...

Type 1 diabetes mellitus (T1DM) is characterized by autoimmune β-cell destruction and absolute insulin deficiency. While insulin remains the cornerstone of treatment, the adjunctive use of oral hypoglycemic agents (OHAs) has been explored, thoug...

Radioguided surgery has become a key component of contemporary breast cancer care, supporting less invasive approaches while maintaining oncologic safety. This narrative review summarizes current practice and recent developments in radioguided breast...

Amiodarone-induced thyrotoxicosis (AIT) is a serious thyroid dysfunction that represents a significant complication of pharmacological therapy in cardiology patients. The development of AIT can substantially complicate the management of cardiac arrhy...

This work describes an efficient and environmentally friendly method for the synthesis of silver-based nanostructures through a green route using Aloe vera extract as a reducing agent, silver nitrate (AgNO₃) as a precursor, and polyvinylpyrrolidone (...

Background: The significance of imaging right-heart thrombus via echocardiography in acute pulmonary embolism (PE) patients, as well as its management, remains uncertain. Methods: In this retrospective, observational, multicenter, and multinational r...

Blood-based biomarkers have emerged as promising, minimally invasive tools for the diagnosis, prognostic stratification, and treatment monitoring of non-small cell lung cancer (NSCLC), including markers of tumor burden, tumor dissemination, immune si...

Introduction: Isolated peroneus longus (PL) tendon tears are rare injuries and an often-overlooked cause of chronic lateral ankle pain. Evidence regarding optimal conservative management, especially in elite athletes, remains limited. Focused extraco...

The growing demand for implant-supported rehabilitative prosthetic treatments has reinforced the need to optimize biomechanical performance, particularly regarding force distribution. This study aimed to evaluate the stress distribution generated by...

Background Biological agents such as infliximab [IFX] and adalimumab [ADA] are employed in the treatment of severe Crohn’s disease [CD], especially in cases refractory to conventional therapies. This study assessed the predictive value of simpl...

Objective. This study performed a comparative analysis of autonomic responses during voluntary breath-holds at inspiration and expiration by assessing low-frequency (LF) oscillations in heart rate (HR) and photoplethysmogram (PPG) signals. Methods. E...

Postural control is a multilevel adaptive system that stabilizes the body in space through dynamic sensory rebalancing and predictive neuromotor regulation. This review synthesizes current data on the neural mechanisms of balance maintenance, individ...

Background/Objectives: Omalizumab is an effective treatment for antihistamine-refractory chronic urticaria. However, post-injection urticaria exacerbation and related adverse reactions remain inconsistently reported. This scoping review mapped eviden...

Firefighters routinely perform short-distance sprints while wearing or carrying occupational gear. Nevertheless, how fatigue interacts with task-specific loading to shape the distribution of mechanical work across lower-limb joints remains poorly und...

Age-related changes in neurotransmitter systems contribute to declines in cognitive, emotional, and motor function, yet the biological mechanisms linking these changes to aging are not completely understood. Epigenetic regulation offers a promising f...

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease affecting the sacroiliac joints and spine and is associated with an increased risk of fractures due to persistent inflammation, reduced mobility and treatment-related factors. In radio...

Background: Post-stroke spasticity is a frequent and disabling consequence of stroke, including when affecting the lower limbs, where it may impair stance, gait, balance, postural control, functional independence and quality of life. Botulinum toxin...

Treatment of non-small cell lung cancer (NSCLC) has been transformed by immunotherapy and targeted therapies. We aimed to characterize clinical features, treatment patterns, and healthcare resource use in patients with early and locally advanced NSCL...

Background: Immune checkpoint inhibitors (ICIs), particularly programmed death-ligand 1 (PD-L1) inhibitors such as atezolizumab, have significantly improved outcomes in cancer therapy. However, these agents may cause immune-related adverse effects, i...

Tear film instability and dry eye disease (DED) are among the most common postoperative complaints after anterior segment surgery. Cataract surgery, corneal refractive procedures, keratoplasty, glaucoma filtration surgery, and pterygium excision can...

Since 2020, recurrent waves of SARS-CoV-2 infection have persisted globally. Despite the advancements in vaccines and pharmacological treatments, a subset of patients still exhibits an aggressive form of COVID-19 requiring prolonged stays in the inte...

Satureja nepeta essential oil (EO) is gaining prominence for its multifaceted pharmacological and biotechnological potential. This study aimed to characterize its volatile profile and evaluate its functional capacity as an antioxidant, antibacterial,...

Background/Objectives: Acromegaly is a chronic endocrine disorder caused mainly by GH-secreting pituitary adenomas, leading to excess GH and elevated IGF-1. Although surgery is first-line therapy, many patients require medical treatment, and remissio...

GRAS transcription factors are crucial regulators governing plant growth and stress adaptation, yet no systematic genome-wide investigation of the GRAS gene family has been reported for coriander, celery and carrot, three economically and medicinally...

Langer’s axillary arch, also known as the axillopectoral muscle, represents a relatively uncommon anatomical variation of the axillary region. Although often asymptomatic, its presence may have important implications in surgical procedures invo...

Bone healing is a complex regenerative process regulated by interactions between skeletal and host biologic responses, and failure of bone repair remains a major challenge in orthopedic surgery. Using a murine model, this study investigated whether a...

Background: Neurovascular coupling (NVC) is a fundamental mechanism that dynamically matches retinal blood flow to neuronal metabolic demand. While dynamic vessel analysis (DVA) has been established for assessing NVC through flicker-light stimulation...

We aimed to investigate the therapeutic effects of alpha-pinene (α-pinene), a major component of phytoncide, in in vitro and in vivo models of mild traumatic brain injury (mTBI), raising the possibility of treating mTBI, a condition currently l...

Respiratory diseases are a major global health challenge. However, identification of respiratory diseases is often limited by subjectivity, environmental noise and inter-clinician variability. This study presents an explainable multimodal deep learni...

Background: The sphenoid sinus occupies a strategically central position at the base of the skull, in close proximity to critical neurovascular structures including the pituitary gland, optic nerves, internal carotid arteries, and the cavernous sinus...

Background/Objectives: Physical activity (PA) and body mass index (BMI) are two central modifiable determinants of cardiometabolic health and functional performance across the adult lifespan. Excess adiposity and physical inactivity frequently coexis...

Placenta accreta spectrum (PAS) is associated with substantial intraoperative hemorrhage. Abdominal aortic balloon occlusion (AABO) has been introduced to mitigate blood loss, though its benefit remains debated. This study, registered at ClinicalTria...

Combination analgesic therapy is commonly used to improve pain control, yet conventional molecular docking approaches typically evaluate individual ligands and provide limited insight into potential intermolecular associations between co-administered...

Variants in the glucocerebrosidase gene (GBA1) are the predominant genetic risk factor for Parkinson’s disease (PD), often accelerating disease progression. While biological sex modulates PD progression, the longitudinal association between ras...

Advanced methodologies for Botryllus schlosseri artificial seawater systems are needed to decrease dependency of large-scale culture on natural seawater and expand this important new model organism to more inland laboratories. We constructed two botr...

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) has been linked to atrial fibrillation (AF); however, its relationship with specific AF subtypes remains unclear. This prospective, single-center, observational case–c...

This systematic literature review synthesizes available data from published case reports and case studies describing de novo myasthenia gravis (MG) following confirmed SARS-CoV-2 infection, focusing on clinical presentation, immunological characteris...

Alternaria brassicicola is a necrotrophic fungal pathogen causing black spot disease on cruciferous crops worldwide. In this study, we comprehensively characterized the pathogenic isolate Ab0920a from diseased broccoli in Shanghai using morphological...

Background/Objectives: Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment in aging populations. While effective treatments exist for neovascular AMD and, more recently, geographic atrophy, no widely accepted t...

Background: Knee osteoarthritis (KOA) is a degenerative joint disorder characterized by chronic pain, functional limitation, and low-grade inflammation. While platelet-rich plasma (PRP) has gained traction as a biologic therapy, the relationship betw...

Human spaceflight in microgravity induces profound physiological adaptations, yet its effects on the sensory system remain comparatively underexplored. While musculoskeletal and cardiovascular changes are well documented, sensory alterations pose equ...

The global burden of diabetes mellitus and its chronic complications—including premature atherosclerotic cardiovascular disease and microvascular impairments such as nephropathy, retinopathy, and neuropathy—highlights the need for improve...

Purpose: To investigate the short-term impact of scleral lens wear on intraocular pressure (IOP) and retinal nerve fiber layer (RNFL) thickness. We hypothesized that scleral lens wear would produce a measurable elevation in IOP accompanied by detecta...

Acromegaly is a rare chronic endocrine disorder characterized by delayed diagnosis, multisystem comorbidity, and heterogeneous therapeutic response. We aimed to describe the clinical characteristics, tumor profile, treatment patterns, biochemical con...

Background: Glioblastoma (used to be called glioblastoma multiforme—GBM) is the most common and aggressive brain tumor, having the lowest overall survival rate. Initial focal neurological deficits are primarily attributable to surrounding edema...

Corneal fibrosis and scarring remain leading causes of vision impairment and blindness globally, particularly following trauma, infection, or surgical intervention. Macrophages, as central mediators of immune and repair responses, orchestrate key pha...

Takotsubo syndrome (TTS) is an acute disorder characterized by transient left ventricular dysfunction with typical regional wall motion abnormalities, most commonly apical ballooning. It accounts for 1–3% of all suspected acute coronary syndrom...

Background: Haller cells (HCs), infraorbital pneumatization of the anterior ethmoidal air cells, are anatomical variants frequently located adjacent to the maxillary sinus ostium. Their presence has been hypothesized to interfere with mucociliary dra...

Background: Pressure injuries are a preventable source of morbidity, mortality, and excess healthcare costs among hospitalized adults. They represent a significant burden in acute and critical care settings in the Eastern Mediterranean region, yet da...

Vernal keratoconjunctivitis (VKC) is a chronic condition that causes remodeling of the cornea and conjunctiva through recurring episodes of allergic inflammation of the ocular surface. This can lead to corneal scarring, keratoconus, and chronic conju...