2026 July-1 - 191 articles
Objectives: To investigate morphometric alterations associated with pediatric migraine without aura at the whole-brain, cerebellar subregional, and thalamic nuclei levels using a multiplatform magnetic resonance imaging (MRI) approach integrating the...
Background/Objectives: Early diagnosis of cardiac amyloidosis is crucial to improve patient outcomes. Although 99mTc-MDP is less sensitive than other bone-avid tracers for detecting ATTR-CA, it is widely used for routine bone imaging in this region....
Recurrence of Takotsubo syndrome (TS) is the most significant challenge in the long-term follow-up of patients with TS. We present the case of a 40-year-old woman with a history of two acute coronary syndromes and myocarditis who was hospitalized in...
Background/Objectives: Sarcoidosis is a multisystem inflammatory disease characterized by heterogeneous clinical manifestations and variable disease severity. Hematological inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), pla...
Iron is essential for normal cellular function, but its dysregulation is increasingly recognized as a key factor in colorectal tumorigenesis. This review provides an integrated overview of iron-related biomarkers across the full spectrum of colorecta...
Background: Transient elastography (TE) is widely used for noninvasive assessment of liver fibrosis. In patients undergoing hemodialysis, however, liver stiffness measurements (LSM) may be affected by rapid intradialytic changes in volume status, ven...
Sarcoidosis is a multisystem disease characterised by a heterogeneous clinical presentation and variable disease course. Despite low mortality, the burden of sarcoidosis extends beyond organ involvement, with many patients reporting significant impai...
Background/Objectives: Predicting how fast a patient with Alzheimer’s disease will decline over the next year remains a challenge. Existing blood transcriptomic studies have not established whether probe selection is reproducible, whether the s...
Background/Objectives: Cardiac troponin I (TnI) is the reference biomarker for detecting myocardial injury. Saliva has recently emerged as a potential non-invasive diagnostic fluid; however, evidence regarding the clinical utility of salivary TnI rem...
Background/Objectives: Keratoconus (KC) is a chronic disease that causes progressive corneal thinning and steepening, thereby negatively impacting visual acuity. Although corneal topography and keratometry are the primary measures to diagnose KC, acc...
Background/Objectives: Abnormal vaginal discharge (AVD) is a common complaint among women of reproductive age, often involving multiple, overlapping etiologies, most commonly bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), aerobic vaginitis...
Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide. This significant burden necessitates effective early identification of pregnancies at high-risk for preeclampsia. Accurate prediction is essential in order t...
Background: Active surveillance (AS) criteria in prostate cancer (PCa) are expanding to include selected patients with intermediate-risk features. This multicenter retrospective study aimed to validate a proposed risk group (RG) classification for pr...
Background/Objectives: Autoimmune hepatitis (AIH) is a chronic immune-mediated liver disease that may progress to cirrhosis and liver failure if not diagnosed early. Although liver biopsy remains the reference standard for fibrosis assessment, its in...
Systemic chronic active Epstein–Barr virus disease (sCAEBV) is a rare and potentially fatal disorder characterized by inflammatory manifestations and organ infiltration by EBV-infected T- or NK-cells. Although [18F]FDG PET/CT has limited utilit...
Background/Objectives: Although ultrasound-guided fine-needle aspiration biopsy with suction (FNA-S) is preferred for evaluating thyroid nodules, the capillary technique (FNA-C) is also used. However, the diagnostic performance of both techniques rem...
Methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) has emerged as a valuable diagnostic, prognostic, and therapeutic biomarker in modern oncologic pathology, primarily serving as a surrogate for CDKN2A/B homozygous deletion due to th...
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, posing a significant and ongoing burden on healthcare systems. Early identification of reliable biomarkers is essential for improving risk stratification, di...
Background/Objectives: Conjunctival hyperemia is a common clinical finding in clinical practice; however there are significant differences between graders. Vessel detection using deep-learning approaches could enable more objective measures. We aimed...
Objectives: Sudden cardiac death (SCD) is a leading cause of mortality, accounting for approximately 50% of all cardiovascular deaths and 20% of all-natural deaths in Western countries. In individuals over 50 years of age, coronary artery disease (CA...
Background/Objectives: RNA virus metagenomic sequencing is a core technology for emerging infectious disease prevention and control, as well as for rapid pathogen identification. However, two major bottlenecks hinder its clinical application: the low...
Background/Objectives: The aim of this study was to assess the diagnostic capabilities of three large language model-based artificial intelligence chatbots (ChatGPT 4.0, Gemini 2.5, and Microsoft Copilot) in the radiographic evaluation of jaw lesions...
Neurofibromatosis type 1 (NF1) is a genetic tumor predisposition syndrome characterized by a substantial risk of developing peripheral nerve sheath tumors, including malignant peripheral nerve sheath tumors (MPNSTs), which occur in 8–13% of pat...
Background/Objectives: Electrocardiogram (ECG)-based myocardial infarction (MI) classifiers may achieve high internal validation performance but show reduced performance when applied to data from another source. The task is a controlled binary health...
Background/Objectives: This study aimed to perform analytical validation and evaluation of the clinical performance of the Access Glial Fibrillary Acidic Protein (GFAP) research-use-only (RUO) immunoassay (Beckman Coulter) in plasma. Methods: A fully...
Background: Preoperative identification of invasive carcinoma in patients with ductal carcinoma in situ (DCIS) remains challenging. While individual imaging findings have been widely investigated, the significance of mass findings identified on both...
Background/Objectives: Fine-needle aspiration biopsy (FNAB) is the primary diagnostic procedure for the evaluation of thyroid nodules. Although considered safe and minimally invasive, its immediate systemic biochemical effects, particularly those rel...
Background: Abdominal pain in hematological patients, particularly during chemotherapy-induced neutropenia, represents a significant diagnostic challenge due to the broad spectrum of potentially life-threatening conditions, including neutropenic ente...
In the original publication [...]
Background/Objectives: To evaluate whether frontal and maxillary sinus hypoplasia/aplasia are associated with differences in CT-based craniofacial morphometric measurements in adults. Methods: This retrospective case–control study included adul...
Background/Objectives: To evaluate the discriminative value of perilesional microstructural alterations assessed by diffusion tensor imaging (DTI) parameters in differentiating malignant and benign causes of intracerebral hemorrhage. Methods: This re...
Backgrounds: Bladder cancer shows pronounced biological heterogeneity that underlies its variable clinical course and prognosis. Our study aims to delineate clinically relevant differences in bladder cancer using an immunohistochemistry-based molecul...
Background/Objectives: The Ishak and Knodell classifications are used to evaluate fibrosis on percutaneous liver biopsy (PLB) in chronic hepatitis (CH). Hepatosteatosis (HS) can also be seen in PLBs performed on patients. In addition to PLB, the shea...
Background/Objectives: Breast cancer is the most commonly diagnosed malignancy among women, with hormone receptor-positive tumors representing the majority of cases. Increasing survival rates have shifted attention toward long-term complications, inc...
Background/Objectives: Maxillary sinuses play an important clinical role due to their location within the visceral cranium and proximity to numerous anatomical structures. In the case of children, considering the ongoing development process, it shoul...
Background/Objectives: Obstructive sleep apnea (OSA) is a common and serious sleep-related disorder that causes repeated interruptions in breathing during sleep. Traditional diagnostic methods, such as polysomnography, are accurate but costly, time-c...
Current acute coronary syndrome (ACS) care relies on sequential, single-modality diagnostics, in which the electrocardiogram, the troponin trajectory, and the coronary angiogram are interpreted independently rather than as a joint signal. This narrat...
Background/Objectives: Transradial access (TRA) is a standard approach in the management of ST-segment elevation myocardial infarction (STEMI); however, evidence on using a single catheter for both diagnostic angiography and percutaneous coronary int...
The co-circulation of respiratory viruses, including SARS-CoV-2, influenza A/B, and respiratory syncytial virus (RSV), represents a significant global health challenge that requires rapid, accurate, and differential diagnosis to support infection con...
Diabetes mellitus (DM) may influence susceptibility to ocular infection and inflammatory phenotypes; however, disease-specific DM prevalence across uveitis etiologies has not been well characterized. We evaluated DM prevalence across major uveitis en...
Multiparametric ultrasound (MPUS) has emerged as a clinically relevant platform for the non-invasive generation of quantitative imaging biomarkers, transforming conventional abdominal sonography from a morphological screening tool into a functional,...
Background/Objectives: Mammographic breast density assessment represents a crucial step in the detection of breast cancer, risk stratification, and lesion visibility. However, it is generally quite difficult to distinguish between intermediate densit...
Background/Objectives: Rapid and accurate ketone detection is clinically valuable for both diabetic and non-diabetic individuals. Breath acetone represents an attractive non-invasive and real-time alternative for monitoring ketones. This study aimed...
Choledocholithiasis after bariatric surgery presents a unique set of challenges for surgeons and gastroenterologists. This narrative review discusses the most common procedural interventions for choledocholithiasis in patients after commonly performe...
Background/Objectives: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine-metabolic disorder. Rotterdam-defined phenotypes may need adjunctive, non-invasive signals for research-level phenotypic stratification. Saliva deserves attention be...
Background: Peripheral nerve sheath tumors of the oral cavity are rare and encompass both benign and malignant entities. Differentiating between these lesions remains challenging due to overlapping clinical and histopathological characteristics. Case...
Background/Objectives: Type 2 diabetes mellitus (T2DM) is a major global health challenge due to its high prevalence and association with chronic complications, highlighting the need for reliable predictive tools to support clinical decision-making....
Aims: The uric acid-to-high-density lipoprotein cholesterol ratio (UHR) has emerged as a potential marker of cardiometabolic dysfunction. However, evidence regarding its association with prediabetes remains limited in Hispanic populations. We evaluat...
Systemic air embolism (SAE) is a rare but potentially catastrophic complication of computed tomography (CT)-guided percutaneous lung procedures, with reported incidence ranging from 0.02% to 0.4%. Despite its low frequency, SAE can result in severe n...
Inflammatory fibroid polyp (IFP) or Vanek’s tumor is a rare benign submucosal lesion of the gastrointestinal tract that may radiologically mimic mesenchymal gastric tumors, particularly gastrointestinal stromal tumors. We present the case of a...
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