8 July 2026
Background/Objectives: Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide, and accurate histopathological tissue segmentation is critical for timely and reliable diagnosis. Healthcare systems represent complex...
8 July 2026
Gestational diabetes (GDM) is a frequent health problem associated with both short- and long-term adverse outcomes for mother and child. Standard management includes lifestyle interventions and, when necessary, pharmacologic therapy. However, the eff...
8 July 2026
Background/Objectives: Multisensory inputs generate a common gravity-reference frame, but just the otoliths sense the gravity vector. Graviception is frequently assessed by setting a luminous line to the subjective visual vertical (S.V.V.). Populatio...
8 July 2026
Background/Objectives: The first permanent molar (M1) is critical for occlusal development but is highly susceptible to caries and molar–incisor hypomineralization (MIH). When M1 prognosis is poor, extraction may be necessary, requiring accurat...
8 July 2026
Background/Objectives: Ovarian cancer (OC) is a leading cause of cancer-related mortality in women, largely driven by late-stage diagnosis. Five-year survival is just 30% for advanced-stage (III-IV) disease but exceeds 90% for early-stage disease, un...
8 July 2026
Background/Objectives: Hypertrophic cardiomyopathy (HCM) is a complex myocardial disease in which structural remodeling extends beyond conventional parameters such as maximal wall thickness (MWT). This study aimed to evaluate isoperimetric analysis a...
8 July 2026
Background: Active tuberculosis (TB) is increasingly recognized as a systemic thrombo-inflammatory condition capable of inducing a clinically relevant hypercoagulable state and increasing the risk of venous thromboembolism, including pulmonary emboli...
8 July 2026
Background/Objectives: Non-invasive prenatal testing (NIPT) performance is influenced by multiple biological and technical factors, including fetal fraction, sequencing depth, library preparation, and bioinformatic processing. This study aimed to com...
8 July 2026
Background/Objectives: Myocardial iron overload is a major contributor to adverse cardiac outcomes in pediatric patients with transfusion-dependent β-thalassemia (TDT). Cardiovascular magnetic resonance (CMR), including T2* and T1 mapping, allow...
8 July 2026
Background: This study aimed to evaluate associations between baseline clinical status, radiological findings, prior medical history, procedural characteristics, and recanalization success with neurological outcome at discharge (NIHSS) and functional...
8 July 2026
Background/Objectives: This study aimed to evaluate the reproducibility of 3D facial skeletal surface models generated from repeated computed tomography (CT) and cone bean CT (CBCT) scans. Methods: Four hydrated-dry skull specimens, with soft-tissue...
7 July 2026
Twelve years after the 2013 fifth edition, the American College of Radiology has released BI-RADS® v2025, with substantial revisions across mammography, ultrasonography, MRI, and the newly independent contrast-enhanced mammography (CEM) section....
7 July 2026
Background/Objectives: Knee injuries and overuse-related disorders are common among athletes participating in jumping sports such as handball and basketball. Musculoskeletal ultrasonography is increasingly used for the assessment of knee pathology; h...
7 July 2026
This review synthesizes recent advances in WHO-endorsed NAATs for TB diagnosis and drug resistance detection. We examine the principles, genetic targets, diagnostic performance, implementation settings, and programmatic role of assays across the spec...
7 July 2026
Background/Objectives: To characterize the zero-shot diagnostic behavior of three commercial multimodal large language models (MLLMs) on cardiopulmonary chest radiograph findings and to assess sex-stratified performance differences. Methods: GPT-5.4,...
Background: Graves’ disease is an autoimmune thyroid disorder that may be accompanied by systemic inflammation and Graves’ orbitopathy. This study evaluated the relationship between readily available hematological inflammatory markers and...
Background/Objectives: Acute pulmonary embolism (PE) is a major cause of cardiovascular mortality, with prognosis influenced by hemodynamic status, comorbidities, and biomarker profiles. Although several laboratory markers have demonstrated prognosti...
Background: Early detection of severe infections in burn patients is difficult due to confounding sterile inflammation. Previous research has shown that Pancreatic Stone Protein (PSP) is less affected by trauma and surgery. Therefore, this study inve...
Skeletal safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) remains uncharted, with emerging evidence suggesting a divergence between mono- and dual-agonist therapies. GLP-1RA monotherapy appears bone-neutral, with modest or no adverse ef...
Background: Stapokibart is a novel biologic for chronic rhinosinusitis with nasal polyps (CRSwNP). We aimed to identify baseline biomarkers predicting early (4-week) and mid-term (16-week) responses to stapokibart in CRSwNP. Methods: A total of 57 pa...
Background/Objectives: Systemic inflammation and nutritional status influence cancer progression and prognosis. The C-reactive protein–albumin–lymphocyte (CALLY) index is a novel biomarker reflecting inflammation, immune response, and nut...
Background: This study aims to assess associations between occurrence of delayed cerebral ischemia (DCI) in spontaneous subarachnoid hemorrhage (SAH) and possible dysfunction of autonomic cardiovascular modulation compared to transcranial Doppler ult...
Background and Clinical Significance: Lambert–Eaton myasthenic syndrome (LEMS) is mediated by antibodies against P/Q-type voltage-gated calcium channels (VGCCs) and is classified as paraneoplastic (T-LEMS) or non-paraneoplastic (NT-LEMS). Cereb...
Background/Objectives: Impacted third molars may adversely affect adjacent second molars, leading to pathological conditions such as external root resorption and dental caries. Accurate assessment of these interactions is important for treatment plan...
To establish a geometric framework for scleral fixation planning in secondary intraocular lens (IOL) implantation that accounts for corneal ellipticity and meridional orientation, and to analyze the limitations of fixed limbus-distance marking. The l...
Background/Objectives: Gastrointestinal bleeding is a critical finding in wireless capsule endoscopy (WCE), but manual examination of thousands of image frames is labor-intensive, time-consuming, and susceptible to missed lesions. This study aimed to...
Background/Objectives: Laboratory automation is a key strategy for increasing productivity and reducing sample turnaround time (TAT), a common indicator of laboratory performance. However, owing to the statistical distribution of TAT values, conventi...
Background/Objectives: The heterogenous nature of renal cell carcinomas (RCCs) is increasingly recognized. The purpose of this proof-of-concept pilot study was to evaluate correlations between multiparametric MRI (mpMRI)-derived and histopathological...
Background: Thymic epithelial tumors (TETs) are the most common primary neoplasms of the anterior mediastinum and present a dual classification challenge, namely anatomical staging according to the Masaoka–Koga system and histological risk stra...
Nephrology is experiencing an ongoing shift toward an era in which kidney diseases are differentiated by their intrinsic biology, rather than by clinical manifestations, histopathology, or changes in kidney function [...]
Background/Objectives: Endocrine-disrupting chemicals (EDCs) interfere with hormonal homeostasis and have been implicated in gynecological malignancy pathogenesis. This narrative review synthesizes current evidence regarding EDC exposure and breast,...
Background/Objectives: Dilated cardiomyopathy is a heterogeneous disorder with a substantial genetic contribution from a variety of pathogenic variants. Hereditary isolated DCM is often caused by variants in genes encoding sarcomere proteins, as well...
Background/Objectives: This study aimed to apply morphometric and multivariate analytical techniques to footprint evidence for forensic identity determination, focusing on sex estimation and the reconstruction of body proportions as components of the...
Background/Objectives. Neurofilament light chain (NfL) is a biomarker of axonal injury with prognostic value in acute ischemic stroke and a promising surrogate outcome marker. This study evaluated whether serum NfL concentrations in ischemic stroke w...
Background/Objectives: Chronic dermatological conditions increasingly require complex and patient-centered therapeutic management, including biologic therapies, injectable treatments, and multidisciplinary care. In this context, patient-reported expe...
Background/Objectives: To develop and evaluate a deep learning-based quality control system for Lumbar Spinal Digital Radiographs (LSDR), designed to automate and improve their evaluation and reduce reliance on manual reviews. Methods: This retrospec...
Background/Objectives: Catatonia is a severe transdiagnostic neuropsychiatric syndrome for which accessible biological correlates remain insufficiently characterized. This study explored whether complete blood count (CBC)-derived inflammatory indices...
Background/Objectives: The clinical utility of renal ultrasound after pediatric urinary tract infection (UTI) remains controversial, particularly because not all ultrasonographic abnormalities have the same prognostic significance. This study aimed t...
The widespread adoption of prostate-specific membrane antigen (PSMA)-targeted PET/CT has profoundly reshaped molecular imaging in prostate cancer and has substantially reduced the routine use of radiolabeled choline tracers. However, the transition f...
Background/Objectives: Major Depressive Disorder is a serious mental disorder that negatively affects an individual’s health and quality of life. The diagnosis of this disease is based on clinical interviews, questionnaires, and the patient&rsq...
Background/Objectives: Persistent and recurrent symptoms after carpal tunnel release remain challenging, and non-surgical options for post-surgical carpal tunnel syndrome (CTS) are poorly defined. This study evaluated 6-month treatment success after...
Pediatric Monteggia fracture-dislocations may be overlooked when ulnar injury is incomplete or plastically deformed and radiocapitellar malalignment is subtle. Radiographic interpretation is further complicated by incomplete ossification, non-standar...
Background/Objectives: The use of quantitative neuroimaging to establish objective biomarkers in neurodegenerative diseases (NDD) has attracted increasing interest over the last decade. Advanced magnetic resonance imaging (MRI) such as arterial spin...
Objectives: To assess the feasibility and reproducibility of predicting antimicrobial resistance (AMR) in Escherichia coli from MALDI-TOF mass spectrometry data using a standardized, open-source machine learning (ML) workflow, we systematically compa...
Background/Objectives: Force platforms and optoelectronic motion capture systems are considered gold standards for postural sway assessment, although their use is confined to dedicated laboratory settings. Wearable inertial systems represent a practi...
Background: Early and objective identification of cognitive decline in aging populations remains a clinical challenge. Pupillary light reflex (PLR) and eye movement parameters represent non-invasive, quantitative biomarkers of autonomic and central n...
Background: Hydrogen breath testing is commonly used to assess intestinal fermentation and diagnose small intestinal bacterial overgrowth (SIBO). However, it remains unclear whether hydrogen production reflects systemic inflammatory or metabolic stat...
Background/Objectives: Colorectal serrated lesions are highly heterogeneous at the micromorphological level. Their morphology can range from seemingly harmless, as in the case of hyperplastic polyps with little to no neoplastic potential, to lesions...
Background: The styloid process exhibits considerable anatomical variability, and its elongation is frequently identified as an incidental finding on panoramic radiographs. However, limited evidence exists regarding its prevalence and possible associ...
Background: MEIS1::NCOA1/2 fusion sarcomas are a recently described molecular entity arising predominantly in the genitourinary and gynecologic tracts. Their clinical presentation is often misleading, and no standardized treatment guidelines currentl...
