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Diagnostics, Volume 16, Issue 13

2026 July-1 - 191 articles

Cover Story: Assessing conjunctival hyperemia using traditional manual grading systems introduces significant inter-observer variability that can hinder consistent clinical monitoring. To overcome these subjective limitations, this study evaluates objective conjunctival vascular metrics calculated via a deep-learning-based automated vessel detection pipeline. Slit lamp images from glaucoma patients were analysed to extract vessel density, fractal dimension, and vessel tortuosity. Both vessel density and fractal dimension demonstrated strong, significant correlations with manual clinical grades as assessed using the Efron scale. These automatically generated vessel metrics offer highly transparent and interpretable features, paving the way for a more reliable and objective biomarker to evaluate hyperemia severity in clinical trials and daily ophthalmic practice. View this paper
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Articles (191)

  • Review
  • Open Access
Diagnostics2026, 16(13), 2135;https://doi.org/10.3390/diagnostics16132135 
(registering DOI)

7 July 2026

Twelve years after the 2013 fifth edition, the American College of Radiology has released BI-RADS® v2025, with substantial revisions across mammography, ultrasonography, MRI, and the newly independent contrast-enhanced mammography (CEM) section....

  • Article
  • Open Access

Ultrasonographic Knee Abnormalities and Their Association with Pain in Young Male Handball and Basketball Athletes: A Cross-Sectional Study

  • Nicoleta Anamaria Pascalau,
  • Alexandru Bogdan Ilieș,
  • Brigitte Osser,
  • Csongor Toth,
  • Gyongyi Osser,
  • Laura Ioana Bondar,
  • Gheorghe Codruț Bulz,
  • Anca Maria Sabău,
  • Mihaela Gavrila-Ardelean and
  • Corina Dalia Toderescu
Diagnostics2026, 16(13), 2134;https://doi.org/10.3390/diagnostics16132134 
(registering DOI)

7 July 2026

Background/Objectives: Knee injuries and overuse-related disorders are common among athletes participating in jumping sports such as handball and basketball. Musculoskeletal ultrasonography is increasingly used for the assessment of knee pathology; h...

  • Review
  • Open Access

Current Landscape of Molecular Diagnostic Tests and Emerging Tools for Tuberculosis and Drug Resistance

  • Safaa El Kassimi,
  • Rkia Eddabra,
  • Bouchra Belkadi,
  • Abdelkarim Filali-Maltouf and
  • Hassan Ait Benhassou
Diagnostics2026, 16(13), 2133;https://doi.org/10.3390/diagnostics16132133 
(registering DOI)

7 July 2026

This review synthesizes recent advances in WHO-endorsed NAATs for TB diagnosis and drug resistance detection. We examine the principles, genetic targets, diagnostic performance, implementation settings, and programmatic role of assays across the spec...

  • Article
  • Open Access
Diagnostics2026, 16(13), 2131;https://doi.org/10.3390/diagnostics16132131 
(registering DOI)

7 July 2026

Background/Objectives: To characterize the zero-shot diagnostic behavior of three commercial multimodal large language models (MLLMs) on cardiopulmonary chest radiograph findings and to assess sex-stratified performance differences. Methods: GPT-5.4,...

  • Article
  • Open Access

Background: Graves’ disease is an autoimmune thyroid disorder that may be accompanied by systemic inflammation and Graves’ orbitopathy. This study evaluated the relationship between readily available hematological inflammatory markers and...

  • Article
  • Open Access

Malignancy as a Predictor and Potential Modifier of Laboratory Biomarker Prognostic Value in Acute Pulmonary Embolism

  • Sonja Salinger,
  • Aleksandra Kozic,
  • Stefan Ilic,
  • Boris Dzudovic,
  • Bojana Subotic,
  • Jovan Matijasevic,
  • Marija Benic,
  • Tamara Kovacevic Preradovic,
  • Ana Kovacevic-Kuzmanovic and
  • Slobodan Obradovic
  • + 4 authors

Background/Objectives: Acute pulmonary embolism (PE) is a major cause of cardiovascular mortality, with prognosis influenced by hemodynamic status, comorbidities, and biomarker profiles. Although several laboratory markers have demonstrated prognosti...

  • Article
  • Open Access

Pancreatic Stone Protein in Burns: Clinical Value of Bedside Testing—A Prospective Pilot Study

  • Moritz Billner,
  • Philipp von Imhoff,
  • Konrad Karcz,
  • Vadym Burchak,
  • Maximilian C. Stumpfe,
  • Celena A. Soergel and
  • Denis Ehrl

Background: Early detection of severe infections in burn patients is difficult due to confounding sterile inflammation. Previous research has shown that Pancreatic Stone Protein (PSP) is less affected by trauma and surgery. Therefore, this study inve...

  • Perspective
  • Open Access

Tracking Bone Loss in GLP-1RA Therapy: The Potential of the Deoxypyridinoline Urine Test

  • Angeliki Margoni,
  • Efthimia K. Basdra and
  • Athanasios G. Papavassiliou

Skeletal safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) remains uncharted, with emerging evidence suggesting a divergence between mono- and dual-agonist therapies. GLP-1RA monotherapy appears bone-neutral, with modest or no adverse ef...

  • Article
  • Open Access

Baseline Inflammatory Biomarkers and Disease Burden for Predicting Response to Stapokibart in CRSwNP

  • Yuzhe Hao,
  • Xiangning Cheng,
  • Yuxuan Liu,
  • Shazhou Li,
  • Bingyue Huo,
  • Ziyi Long,
  • Qianxue Hu,
  • Tianjian Xie,
  • Lijun Du and
  • Jianjun Chen
  • + 6 authors

Background: Stapokibart is a novel biologic for chronic rhinosinusitis with nasal polyps (CRSwNP). We aimed to identify baseline biomarkers predicting early (4-week) and mid-term (16-week) responses to stapokibart in CRSwNP. Methods: A total of 57 pa...

  • Article
  • Open Access

Prognostic Impact of Immune-Inflammatory and Nutritional Indices in Metastatic Hormone-Sensitive Prostate Cancer

  • Mehmet Nuri Baser,
  • Ahmet Baklaci,
  • Ahmet Unlu,
  • Asim Armagan Aydin,
  • Zeynel Umut Alpsoy,
  • Suleyman Utku Uzun and
  • Bilgin Demir

Background/Objectives: Systemic inflammation and nutritional status influence cancer progression and prognosis. The C-reactive protein–albumin–lymphocyte (CALLY) index is a novel biomarker reflecting inflammation, immune response, and nut...

  • Article
  • Open Access

Associations Between Delayed Cerebral Ischemia in Spontaneous Subarachnoid Hemorrhage and Dysfunction of Autonomic Cardiovascular Modulation Compared to Transcranial Doppler Ultrasound Findings

  • Matthias C. Borutta,
  • Chiara Vetter,
  • Florian Kraemer,
  • Stefan T. Gerner,
  • Kosmas Macha,
  • Ludwig Singer,
  • Tobias Engelhorn,
  • Arnd Doerfler,
  • Stefan Schwab and
  • Julia Koehn

Background: This study aims to assess associations between occurrence of delayed cerebral ischemia (DCI) in spontaneous subarachnoid hemorrhage (SAH) and possible dysfunction of autonomic cardiovascular modulation compared to transcranial Doppler ult...

  • Case Report
  • Open Access

Autopsy-Confirmed Non-Paraneoplastic Lambert–Eaton Myasthenic Syndrome with Cerebellar Degeneration: A Case Report

  • Hajime Iwata,
  • Jun Ikezawa,
  • Masayuki Honda,
  • Ryo Morishima,
  • Yuta Amagasaki,
  • Tomonari Seki,
  • Takahiro Kiriu,
  • Keisuke Ishizawa,
  • Kazushi Takahashi and
  • Haruka Okada

Background and Clinical Significance: Lambert–Eaton myasthenic syndrome (LEMS) is mediated by antibodies against P/Q-type voltage-gated calcium channels (VGCCs) and is classified as paraneoplastic (T-LEMS) or non-paraneoplastic (NT-LEMS). Cereb...

  • Article
  • Open Access

Background/Objectives: Impacted third molars may adversely affect adjacent second molars, leading to pathological conditions such as external root resorption and dental caries. Accurate assessment of these interactions is important for treatment plan...

  • Technical Note
  • Open Access

Meridian-Dependent Geometric Planning for Pars Plana Scleral Fixation: An Orientation-Adjusted Analytical Model

  • Goran Marić,
  • Danny A. Mammo,
  • Damir Godec,
  • Milan Pešić and
  • Zoran Vatavuk

To establish a geometric framework for scleral fixation planning in secondary intraocular lens (IOL) implantation that accounts for corneal ellipticity and meridional orientation, and to analyze the limitations of fixed limbus-distance marking. The l...

  • Article
  • Open Access

An End-to-End Deep Learning System for Gastrointestinal Bleeding Detection and Quantification in Wireless Capsule Endoscopy

  • Mujeeb Rahman Kanhira Kadavath,
  • Aman Kitaz,
  • Nour El Houda Benyahia and
  • Shatha Hussein

Background/Objectives: Gastrointestinal bleeding is a critical finding in wireless capsule endoscopy (WCE), but manual examination of thousands of image frames is labor-intensive, time-consuming, and susceptible to missed lesions. This study aimed to...

  • Article
  • Open Access

Background/Objectives: Laboratory automation is a key strategy for increasing productivity and reducing sample turnaround time (TAT), a common indicator of laboratory performance. However, owing to the statistical distribution of TAT values, conventi...

  • Article
  • Open Access

Tumor Heterogeneity of RCCs Assessed by mpMRI with Direct Radiological–Histopathological Correlation

  • Antonia M. Pausch,
  • Viktoria S. Hadnagy,
  • Toni Rabadi,
  • Daniel Eberli,
  • Niels J. Rupp and
  • Andreas M. Hötker

Background/Objectives: The heterogenous nature of renal cell carcinomas (RCCs) is increasingly recognized. The purpose of this proof-of-concept pilot study was to evaluate correlations between multiparametric MRI (mpMRI)-derived and histopathological...

  • Article
  • Open Access

Machine Learning-Based Prediction of Masaoka–Koga Stage and WHO Histological Risk Group in Thymic Epithelial Tumors Using Biomarker Combinations

  • Konstantinos Kitrou,
  • Georgios Mandrakis,
  • Georgios Tsirogiannis,
  • Stamatios Theocharis,
  • Constantinos Halkiopoulos and
  • Yannis Stamatiou

Background: Thymic epithelial tumors (TETs) are the most common primary neoplasms of the anterior mediastinum and present a dual classification challenge, namely anatomical staging according to the Masaoka–Koga system and histological risk stra...

  • Review
  • Open Access

Endocrine Disruptors and Gynecological Malignancies

  • Dimitris Baroutis,
  • Eleni Katsianou,
  • Konstantinos Koukoumpanis,
  • Ioannis Fragiskos,
  • Nikolaos Sindos,
  • Michael Sindos and
  • George Daskalakis

Background/Objectives: Endocrine-disrupting chemicals (EDCs) interfere with hormonal homeostasis and have been implicated in gynecological malignancy pathogenesis. This narrative review synthesizes current evidence regarding EDC exposure and breast,...

  • Article
  • Open Access

Genetic Testing Yield for Dilated Cardiomyopathy in a Single Lithuanian Center

  • Marius Šukys,
  • Eglė Ereminienė,
  • Kristina Aleknavičienė,
  • Rimvydas Jonikas,
  • Karolina Mėlinytė-Ankudavičė,
  • Paulius Bučius and
  • Rasa Ugenskienė

Background/Objectives: Dilated cardiomyopathy is a heterogeneous disorder with a substantial genetic contribution from a variety of pathogenic variants. Hereditary isolated DCM is often caused by variants in genes encoding sarcomere proteins, as well...

  • Article
  • Open Access

Background/Objectives: This study aimed to apply morphometric and multivariate analytical techniques to footprint evidence for forensic identity determination, focusing on sex estimation and the reconstruction of body proportions as components of the...

  • Article
  • Open Access

Renal Function and Serum Neurofilament Light Chain in Acute Ischemic Stroke: An Observational Cohort Study

  • Federica Ferrari,
  • Nicola Davide Loizzo,
  • Federico Mazzacane,
  • Beatrice Del Bello,
  • Salvatore Console,
  • Silvia Scaranzin,
  • Chiara Morandi,
  • Matteo Gastaldi,
  • Alessandra Persico and
  • Anna Cavallini

Background/Objectives. Neurofilament light chain (NfL) is a biomarker of axonal injury with prognostic value in acute ischemic stroke and a promising surrogate outcome marker. This study evaluated whether serum NfL concentrations in ischemic stroke w...

  • Article
  • Open Access

Patient-Reported Experiences in Chronic Dermatological Conditions: Validation of the Romanian PSPSQ 2.0 Within Contemporary Dermatologic Care Pathways

  • Nicoleta Cirstea,
  • Delia Mirela Tit,
  • Mirela Marioara Toma,
  • Anamaria Lavinia Purza,
  • Ada Radu,
  • Gabriela S. Bungau,
  • Ruxandra-Cristina Marin,
  • Călin Muntean,
  • Georgiana Iris Tit and
  • Radu Dumitru Moleriu

Background/Objectives: Chronic dermatological conditions increasingly require complex and patient-centered therapeutic management, including biologic therapies, injectable treatments, and multidisciplinary care. In this context, patient-reported expe...

  • Article
  • Open Access

Towards Automated Quality Assurance: Integrating Deep Learning and Classical ML into the Digital Radiography Pipeline

  • Hsuan-Yu Chen,
  • Cheng-Fu Chou,
  • Sheng-Hung Liao,
  • Meng-Hsun Wu,
  • Kuan-Yi Chen,
  • Ta-Wei Yang,
  • Jungwei Wilfred Fan and
  • Chih-Hao Chang

Background/Objectives: To develop and evaluate a deep learning-based quality control system for Lumbar Spinal Digital Radiographs (LSDR), designed to automate and improve their evaluation and reduce reliance on manual reviews. Methods: This retrospec...

  • Article
  • Open Access
59 Views
14 Pages

Complete Blood Count-Derived Inflammatory Indices in Catatonia: A Retrospective Matched Case–Control Study

  • Octavia Căpățînă,
  • Adela Hanga,
  • Sonia Tivadar,
  • Andrei Hopulele-Petri,
  • Denis Paval and
  • Mihaela Fadgyas Stanculete

Background/Objectives: Catatonia is a severe transdiagnostic neuropsychiatric syndrome for which accessible biological correlates remain insufficiently characterized. This study explored whether complete blood count (CBC)-derived inflammatory indices...

  • Article
  • Open Access
125 Views
16 Pages

Urological Malformations Identify the High-Burden Phenotype Among Children Hospitalized for Presumed Urinary Tract Infection: A Retrospective Cohort

  • Ana C. Espíritu-Mojarro,
  • Gustavo A. Hernández-Fuentes,
  • Gabriela E. Pedroza-Orozco,
  • José Guzmán-Esquivel,
  • Jesús Venegas-Ramírez,
  • Ileana Y. Ceja-Claro,
  • Daniel A. Montes-Galindo,
  • Carmen A. Sánchez-Ramírez,
  • Mercedes Fuentes-Murguia and
  • Iván Delgado-Enciso
  • + 4 authors

Background/Objectives: The clinical utility of renal ultrasound after pediatric urinary tract infection (UTI) remains controversial, particularly because not all ultrasonographic abnormalities have the same prognostic significance. This study aimed t...

  • Review
  • Open Access
109 Views
13 Pages

Choline PET/CT in the PSMA Era: Clinical Repositioning, Biological Perspectives, and Emerging Applications

  • Virginia Rossetti,
  • Lorenzo Fantini,
  • Irene Marini,
  • Monica Celli,
  • Ilaria Grassi,
  • Maddalena Sansovini,
  • Silvia Nicolini,
  • Federica Matteucci and
  • Paola Caroli

The widespread adoption of prostate-specific membrane antigen (PSMA)-targeted PET/CT has profoundly reshaped molecular imaging in prostate cancer and has substantially reduced the routine use of radiolabeled choline tracers. However, the transition f...

  • Article
  • Open Access
162 Views
26 Pages

Background/Objectives: Major Depressive Disorder is a serious mental disorder that negatively affects an individual’s health and quality of life. The diagnosis of this disease is based on clinical interviews, questionnaires, and the patient&rsq...

  • Article
  • Open Access
174 Views
20 Pages

Background/Objectives: Persistent and recurrent symptoms after carpal tunnel release remain challenging, and non-surgical options for post-surgical carpal tunnel syndrome (CTS) are poorly defined. This study evaluated 6-month treatment success after...

  • Review
  • Open Access
166 Views
25 Pages

Pediatric Monteggia fracture-dislocations may be overlooked when ulnar injury is incomplete or plastically deformed and radiocapitellar malalignment is subtle. Radiographic interpretation is further complicated by incomplete ossification, non-standar...

  • Article
  • Open Access
146 Views
16 Pages

Integrating Metabolic, Perfusion, and Microstructural Parameters for Quantitative Neuroimaging in Rare Neurodegenerative Diseases: A Hybrid PET/MRI Approach

  • Joachim Strobel,
  • Hans-Peter Müller,
  • Laura Michelberger,
  • Anastasia Nosanova,
  • Wolfgang Thaiss,
  • Karl Georg Haeusler,
  • Jochen H. Weishaupt,
  • Kornelia Kreiser,
  • Ambros J. Beer and
  • Nico Sollmann
  • + 2 authors

Background/Objectives: The use of quantitative neuroimaging to establish objective biomarkers in neurodegenerative diseases (NDD) has attracted increasing interest over the last decade. Advanced magnetic resonance imaging (MRI) such as arterial spin...

  • Article
  • Open Access
162 Views
26 Pages

Machine Learning-Based Prediction of Antimicrobial Resistance in Escherichia coli from MALDI-TOF Mass Spectrometry Data

  • Nick Versmessen,
  • Marieke Mispelaere,
  • Robin Vanstokstraeten,
  • Mariana Teixeira,
  • Jerina Boelens,
  • Cedric Hermans,
  • Marjolein Vandekerckhove,
  • Katleen Vranckx,
  • Paco Hulpiau and
  • Piet Cools
  • + 2 authors

Objectives: To assess the feasibility and reproducibility of predicting antimicrobial resistance (AMR) in Escherichia coli from MALDI-TOF mass spectrometry data using a standardized, open-source machine learning (ML) workflow, we systematically compa...

  • Systematic Review
  • Open Access
140 Views
21 Pages

Validity of Wearable Inertial Sensors for Postural Sway Analysis: A Systematic Review

  • Giuseppe Prisco,
  • Noemi Pisani,
  • Maria Romano,
  • Francesco Amato,
  • Fabrizio Esposito and
  • Leandro Donisi

Background/Objectives: Force platforms and optoelectronic motion capture systems are considered gold standards for postural sway assessment, although their use is confined to dedicated laboratory settings. Wearable inertial systems represent a practi...

  • Article
  • Open Access
101 Views
18 Pages

Background: Early and objective identification of cognitive decline in aging populations remains a clinical challenge. Pupillary light reflex (PLR) and eye movement parameters represent non-invasive, quantitative biomarkers of autonomic and central n...

  • Article
  • Open Access
91 Views
16 Pages

Background: Hydrogen breath testing is commonly used to assess intestinal fermentation and diagnose small intestinal bacterial overgrowth (SIBO). However, it remains unclear whether hydrogen production reflects systemic inflammatory or metabolic stat...

  • Article
  • Open Access
148 Views
18 Pages

Diagnostic Significance of Ki-67, p53, and Mucin Glycoprotein Expression in Colorectal Serrated Lesions: Further Immunohistochemical Studies

  • Ivan Ilić,
  • Pavle Ranđelović,
  • Ilija Golubović,
  • Milan Lazarević,
  • Maja Jovičić Milentijević,
  • Biljana Radovanović Dinić,
  • Ivana Đorđević,
  • Jana Cvetković and
  • Milica Veljković

Background/Objectives: Colorectal serrated lesions are highly heterogeneous at the micromorphological level. Their morphology can range from seemingly harmless, as in the case of hyperplastic polyps with little to no neoplastic potential, to lesions...

  • Article
  • Open Access
206 Views
17 Pages

Styloid Process Elongation as an Incidental Finding in Adult Orthodontic Patients: Prevalence, Morphology and Diagnostic Implications from Panoramic Radiography

  • César Martínez-Rodríguez,
  • Alfonso Alvarado-Lorenzo,
  • José María Alamán-Fernández,
  • Juan Santos-Marino,
  • María Andrés-Veiga and
  • Natalia Martínez-Rodríguez

Background: The styloid process exhibits considerable anatomical variability, and its elongation is frequently identified as an incidental finding on panoramic radiographs. However, limited evidence exists regarding its prevalence and possible associ...

  • Case Report
  • Open Access
200 Views
16 Pages

MEIS1::NCOA2 Fusion Sarcoma of the Bartholin Gland: A Case Report and Review of the Literature

  • Pauline Dumonceaux,
  • Loréane Sims,
  • Aline Francois,
  • Sabrina Croce,
  • Latifa Fellah,
  • Sophie Cvilic,
  • Charlotte Maillard and
  • Pascale Jadoul

Background: MEIS1::NCOA1/2 fusion sarcomas are a recently described molecular entity arising predominantly in the genitourinary and gynecologic tracts. Their clinical presentation is often misleading, and no standardized treatment guidelines currentl...

  • Review
  • Open Access
190 Views
18 Pages

The diagnostic evaluation of interstitial lung diseases (ILDs) remains challenging when clinical assessment and imaging findings are inconclusive. Although surgical lung biopsy has traditionally represented the diagnostic gold standard, its invasiven...

  • Article
  • Open Access
214 Views
31 Pages

Background: Chest X-ray imaging is a widely used diagnostic modality for identifying various lung diseases. Accurate multiclass classification of lung diseases enables timely treatment and improves patient survival. However, disease detection using c...

  • Systematic Review
  • Open Access
117 Views
29 Pages

Background: Wrist-hand radiographic skeletal maturation methods are widely used for forensic age estimation of living individuals, remaining among the most widely accepted imaging modalities in forensic practice despite limited evidence supporting th...

  • Article
  • Open Access
109 Views
15 Pages

Background/Objectives: Frailty is a clinically significant syndrome in older patients with ischemic heart disease, associated with adverse outcomes including hospitalization, disability, and mortality. This study aimed to evaluate the association of...

  • Article
  • Open Access
176 Views
16 Pages

Background: Malaria is a life-threatening disease caused by Plasmodium species, which is endemic in tropical and subtropical regions worldwide. In clinical settings, experienced parasitologists perform microscopic examinations of thick/thin blood sli...

  • Article
  • Open Access
183 Views
16 Pages

Epidemic Mitigation and Marginal Mortality Gains Using Self-Testing as a Diagnostic Intervention for Epidemic-Prone Diseases in Africa

  • Yasmin Dunkley,
  • Elizabeth L. Corbett,
  • Nicola Desmond,
  • Pitchaya Indravudh and
  • Nimalan Arinaminpathy

Background/Objectives: African Union (AU) guidance identifies decentralized diagnostics as central to epidemic preparedness. However, the epidemiological role of self-testing across epidemic-prone diseases remains underexplored. Drivers for the poten...

  • Systematic Review
  • Open Access
209 Views
29 Pages

Auditory Electrophysiological Findings in Children with Developmental Language Disorder: A Systematic Review

  • Diego Lourenço dos Santos Silva,
  • Dandara Felipini,
  • Piotr Henryk Skarzynski,
  • Caroline Donadon and
  • Milaine Dominici Sanfins

Background/Objectives: Developmental Language Disorder (DLD) is a persistent neurodevelopmental condition with an estimated prevalence of 7% in preschoolers. It is characterized by significant impairments in language acquisition and use, in the absen...

  • Article
  • Open Access
156 Views
13 Pages

Background: Loculated pleural effusion—characterized by fibrinous septations that compartmentalize the pleural space and impede drainage—is a technically demanding indication for percutaneous catheter drainage (PCD), in which accurate cat...

  • Review
  • Open Access
214 Views
22 Pages

Evaluation of Kidney Function in Cirrhosis: Methods and Pitfalls

  • Fernando Gil-Lopez,
  • Namrata Parikh,
  • Martin Mai,
  • Razvan Chirila and
  • Hani M. Wadei

Renal dysfunction is highly prevalent among patients with cirrhosis and has major implications for management, prognostication, and liver transplant decision-making. Both acute kidney injury (AKI) and chronic kidney disease (CKD) occur frequently in...

  • Article
  • Open Access
125 Views
11 Pages

Objective: This study examined whether HFE H63D carriers living at moderate-to-high altitude have a stronger secondary polycythemia phenotype than non-carriers from the same region. Methods: This retrospective cohort study included 59 patients with H...

  • Article
  • Open Access
159 Views
14 Pages

Background: Impacted maxillary canines frequently cause external root resorption of adjacent lateral incisors, a complication that may compromise tooth survival and orthodontic outcomes. Cone-beam computed tomography (CBCT) enables precise three-dime...

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Diagnostics - ISSN 2075-4418