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  • Review
  • Open Access
7 Citations
3,041 Views
18 Pages

Development of Advanced Imaging and Molecular Imaging for Barrett’s Neoplasia

  • Kaname Uno,
  • Tomoyuki Koike,
  • Waku Hatta,
  • Masahiro Saito,
  • Mizuki Tanabe and
  • Atsushi Masamune

8 October 2022

Barrett esophagus (BE) is a precursor to a life-threatening esophageal adenocarcinoma (EAC). Surveillance endoscopy with random biopsies is recommended for early intervention against EAC, but its adherence in the clinical setting is poor. Dysplastic...

  • Review
  • Open Access
7 Citations
4,892 Views
27 Pages

Multimodality Imaging in Advanced Heart Failure for Diagnosis, Management and Follow-Up: A Comprehensive Review

  • Valeria Pergola,
  • Matteo Cameli,
  • Giulia Mattesi,
  • Saima Mushtaq,
  • Antonello D’Andrea,
  • Andrea Igoren Guaricci,
  • Maria Concetta Pastore,
  • Filippo Amato,
  • Carlo Maria Dellino and
  • on behalf of the Cluster Imaging of Italian Society of Cardiology (SIC)
  • + 8 authors

12 December 2023

Advanced heart failure (AHF) presents a complex landscape with challenges spanning diagnosis, management, and patient outcomes. In response, the integration of multimodality imaging techniques has emerged as a pivotal approach. This comprehensive rev...

  • Review
  • Open Access
54 Citations
10,273 Views
30 Pages

Advanced Imaging Techniques for Radiotherapy Planning of Gliomas

  • Antonella Castellano,
  • Michele Bailo,
  • Francesco Cicone,
  • Luciano Carideo,
  • Natale Quartuccio,
  • Pietro Mortini,
  • Andrea Falini,
  • Giuseppe Lucio Cascini and
  • Giuseppe Minniti

3 March 2021

The accuracy of target delineation in radiation treatment (RT) planning of cerebral gliomas is crucial to achieve high tumor control, while minimizing treatment-related toxicity. Conventional magnetic resonance imaging (MRI), including contrast-enhan...

  • Review
  • Open Access
20 Citations
6,371 Views
23 Pages

Advanced Magnetic Resonance Imaging in the Evaluation of Treated Glioblastoma: A Pictorial Essay

  • Matia Martucci,
  • Rosellina Russo,
  • Carolina Giordano,
  • Chiara Schiarelli,
  • Gabriella D’Apolito,
  • Laura Tuzza,
  • Francesca Lisi,
  • Giuseppe Ferrara,
  • Francesco Schimperna and
  • Simona Gaudino
  • + 2 authors

26 July 2023

MRI plays a key role in the evaluation of post-treatment changes, both in the immediate post-operative period and during follow-up. There are many different treatment’s lines and many different neuroradiological findings according to the treatm...

  • Feature Paper
  • Article
  • Open Access
62 Citations
10,138 Views
15 Pages

Fast Volumetric Ultrasound B-Mode and Doppler Imaging with a New High-Channels Density Platform for Advanced 4D Cardiac Imaging/Therapy

  • Lorena Petrusca,
  • François Varray,
  • Rémi Souchon,
  • Adeline Bernard,
  • Jean-Yves Chapelon,
  • Hervé Liebgott,
  • William Apoutou N’Djin and
  • Magalie Viallon

29 January 2018

A novel ultrasound (US) high-channels platform is a pre-requisite to open new frontiers in diagnostic and/or therapy by experimental implementation of innovative advanced US techniques. To date, a few systems with more than 1000 transducers permit fu...

  • Review
  • Open Access
11 Citations
4,936 Views
31 Pages

Heart Failure and Cardiomyopathies: CT and MR from Basics to Advanced Imaging

  • Pierpaolo Palumbo,
  • Ester Cannizzaro,
  • Maria Michela Palumbo,
  • Annamaria Di Cesare,
  • Federico Bruno,
  • Chiara Acanfora,
  • Antonella Arceri,
  • Laura Evangelista,
  • Francesco Arrigoni and
  • Ernesto Di Cesare
  • + 8 authors

23 September 2022

Since 1997, heart failure (HF) has been designated as a new epidemic. However, it is not easy to find a proper definition since different descriptors are used in clinical practice. Moreover, HF is not a single clinical entity, and there is a close re...

  • Article
  • Open Access
259 Views
28 Pages

Advanced Digital Imaging Assessment Method for Testing Surface Fuzzing in Textile Materials

  • Juro Živičnjak,
  • Antoneta Tomljenović,
  • Maja Somogyi Škoc and
  • Željko Penava

19 June 2026

Textile materials made from staple fibers typically have protruding fibers on their surface, commonly referred to as surface hairiness. During fraying, the surface of the textile material is susceptible to damage, which affects its appearance and lea...

  • Feature Paper
  • Article
  • Open Access
23 Citations
4,179 Views
15 Pages

Hybrid Encryption Scheme for Medical Imaging Using AutoEncoder and Advanced Encryption Standard

  • Yasmeen Alslman,
  • Eman Alnagi,
  • Ashraf Ahmad,
  • Yousef AbuHour,
  • Remah Younisse and
  • Qasem Abu Al-haija

30 November 2022

Recently, medical image encryption has gained special attention due to the nature and sensitivity of medical data and the lack of effective image encryption using innovative encryption techniques. Several encryption schemes have been recommended and...

  • Article
  • Open Access
8 Citations
2,819 Views
13 Pages

Fabrication and Advanced Imaging Characterization of Magnetic Aerogel-Based Thin Films for Water Decontamination

  • Adelina-Gabriela Niculescu,
  • Bogdan Mihaiescu,
  • Alexandra Cătălina Bîrcă,
  • Alina Moroșan,
  • Oana Maria Munteanu (Mihaiescu),
  • Bogdan Ștefan Vasile,
  • Tony Hadibarata,
  • Daniela Istrati,
  • Dan Eduard Mihaiescu and
  • Alexandru Mihai Grumezescu

11 June 2024

Aerogels have emerged as appealing materials for various applications due to their unique features, such as low density, high porosity, high surface area, and low thermal conductivity. Aiming to bring the advantages of these materials to the environm...

  • Article
  • Open Access
17 Citations
5,094 Views
17 Pages

MR Thermometry Accuracy and Prospective Imaging-Based Patient Selection in MR-Guided Hyperthermia Treatment for Locally Advanced Cervical Cancer

  • Iva VilasBoas-Ribeiro,
  • Sergio Curto,
  • Gerard C. van Rhoon,
  • Martine Franckena and
  • Margarethus M. Paulides

13 July 2021

The efficacy of a hyperthermia treatment depends on the delivery of well-controlled heating; hence, accurate temperature monitoring is essential for ensuring effective treatment. For deep pelvic hyperthermia, there are no comprehensive and systematic...

  • Article
  • Open Access
446 Views
16 Pages

Significant Correlation of Dynamic Pan-Immune Inflammation Value and Magnetic Resonance Imaging Response in Patients with Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy

  • Sukran Celikarslan,
  • Duygu Karahacioglu,
  • Bengi Gurses,
  • Fatih Selcukbiricik,
  • Emre Balik,
  • Derya Salim Uymaz,
  • Ahmet Rencuzogullari,
  • Dursun Bugra,
  • Sahin Lacin and
  • Ugur Selek
  • + 13 authors

Background: Accurate identification of complete or near-complete responders after total neoadjuvant therapy (TNT) is critical for selecting candidates for non-operative management in locally advanced rectal cancer (LARC). While static inflammatory bi...

  • Review
  • Open Access
5 Citations
1,268 Views
24 Pages

Coronary Plaque Vulnerability and Pericoronary Adipose Tissue Inflammation: Emerging Insights from Advanced CT Imaging

  • Botond Barna Mátyás,
  • Imre Benedek,
  • Nóra Rat,
  • Renáta Gerculy and
  • Theodora Benedek

26 March 2026

Cardiovascular emergencies most frequently arise from the sudden destabilization of atherosclerotic plaques. Conventional diagnostic strategies predominantly focus on luminal stenosis, despite the fact that most acute coronary events originate from n...

  • Article
  • Open Access
15 Citations
3,754 Views
12 Pages

19 February 2021

Obtaining key and rich visual information under sophisticated road conditions is one of the key requirements for advanced driving assistance. In this paper, a newfangled end-to-end model is proposed for advanced driving assistance based on the fusion...

  • Article
  • Open Access
2 Citations
1,460 Views
20 Pages

Sports image classification has gained increasing significance in various domains, including athlete training, event management, and broadcasting. Nonetheless, accurately classifying these images remains a formidable challenge due to factors such as...

  • Article
  • Open Access
20 Citations
6,289 Views
13 Pages

3 September 2018

With the increasing use of multimedia in communications, the content security of remote-sensing images attracts much attention in both the academia and industry. The Advanced Encryption Standard (AES) is a famous symmetric cryptosystem. A symmetric r...

  • Article
  • Open Access
1 Citations
2,010 Views
10 Pages

27 August 2024

Background: Positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) is a firmly established tool in oncology and is gaining importance in dermato-oncology. However, its use in advanced basal cell carcinoma (BCC...

  • Review
  • Open Access
1,288 Views
21 Pages

The Role of Advanced MR Imaging in Gliomas

  • Anastasia K. Zikou,
  • Eleni Romeo,
  • George A. Alexiou,
  • Marios Lampros,
  • Spyridon Voulgaris,
  • Loukas Astrakas and
  • Maria I. Argyropoulou

20 January 2026

Gliomas are a significant health problem with a lot of imaging challenges. The role of imaging is no longer limited to only providing anatomic details, but with the advancement of Magnetic Resonance Imaging (MRI) techniques, it now permits the assess...

  • Review
  • Open Access
87 Citations
11,746 Views
28 Pages

From Photons to Pixels: Processing Data from the Advanced Baseline Imager

  • Satya Kalluri,
  • Christian Alcala,
  • James Carr,
  • Paul Griffith,
  • William Lebair,
  • Dan Lindsey,
  • Randall Race,
  • Xiangqian Wu and
  • Spencer Zierk

26 January 2018

The Advanced Baseline Imager (ABI) is the primary Earth observing sensor on the new generation Geostationary Operational Environmental Satellites (GOES-R) series, and provides significant spectral, spatial and temporal observational enhancements comp...

  • Article
  • Open Access
11 Citations
2,606 Views
20 Pages

Advanced Fuzzy Sets and Genetic Algorithm Optimizer for Mammographic Image Enhancement

  • Anastasios Dounis,
  • Andreas-Nestor Avramopoulos and
  • Maria Kallergi

A well-researched field is the development of Computer Aided Diagnosis (CADx) Systems for the benign-malignant classification of abnormalities detected by mammography. Due to the nature of the breast parenchyma, there are significant uncertainties ab...

  • Review
  • Open Access
31 Citations
7,594 Views
24 Pages

Advanced Ultrasound and Photoacoustic Imaging in Cardiology

  • Min Wu,
  • Navchetan Awasthi,
  • Nastaran Mohammadian Rad,
  • Josien P. W. Pluim and
  • Richard G. P. Lopata

28 November 2021

Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. An effective management and treatment of CVDs highly relies on accurate diagnosis of the disease. As the most common imaging technique for clinical diagnosis of the CVDs, US...

  • Review
  • Open Access
26 Citations
8,209 Views
14 Pages

Advanced Imaging for Robotic Bronchoscopy: A Review

  • Nakul Ravikumar,
  • Elliot Ho,
  • Ajay Wagh and
  • Septimiu Murgu

Recent advances in navigational platforms have led bronchoscopists to make major strides in diagnostic interventions for pulmonary parenchymal lesions. Over the last decade, multiple platforms including electromagnetic navigation and robotic bronchos...

  • Systematic Review
  • Open Access
1,355 Views
26 Pages

23 February 2026

Background: Stroke is a leading cause of mortality and long-term disability, and aphasia is among its most common and debilitating sequelae. Diffusion tensor imaging (DTI) and advanced diffusion imaging techniques enable the assessment of white matte...

  • Review
  • Open Access
10 Citations
3,512 Views
18 Pages

Advanced Imaging for Localized Prostate Cancer

  • Patrick Albers and
  • Adam Kinnaird

15 October 2024

Background/Objectives: Prostate cancer is a prevalent malignancy often presenting without early symptoms. Advanced imaging technologies have revolutionized its diagnosis and management. This review discusses the principles, benefits, and clinical app...

  • Article
  • Open Access
2,529 Views
12 Pages

The Role of Surveillance Imaging in Patients with Advanced Laryngeal Cancer

  • Eyal Yosefof,
  • Sharon Tzelnick,
  • Yuval Nachalon,
  • Uri Alkan,
  • Ido Amir,
  • Michal Tunik,
  • Hagit Shoffel-Havakuk,
  • Noga Kurman,
  • Ohad Hilly and
  • Yaniv Hamzany
  • + 1 author

24 February 2024

Background: While almost one-third of patients treated for laryngeal cancer will experience disease recurrence, the current National Comprehensive Cancer Network guidelines do not recommend routine post-treatment imaging follow-up. We aimed to examin...

  • Communication
  • Open Access
1 Citations
2,292 Views
11 Pages

Advanced Sandwich Composite Cores for Patient Support in Advanced Clinical Imaging and Oncology Treatment

  • Robert H. Morris,
  • Nicasio R. Geraldi,
  • Lucy C. Pike,
  • Jörg Pawelke,
  • Aswin L. Hoffmann,
  • Nicola Doy,
  • Johanna L. Stafford,
  • Abi Spicer and
  • Michael I. Newton

12 August 2020

Ongoing advances in both imaging and treatment for oncology purposes have seen a significant rise in the use of not only the individual imaging modalities, but also their combination in single systems such as Positron Emission Tomography combined wit...

  • Article
  • Open Access
34 Citations
7,081 Views
19 Pages

Generation and Evaluation of LAI and FPAR Products from Himawari-8 Advanced Himawari Imager (AHI) Data

  • Yepei Chen,
  • Kaimin Sun,
  • Chi Chen,
  • Ting Bai,
  • Taejin Park,
  • Weile Wang,
  • Ramakrishna R. Nemani and
  • Ranga B. Myneni

27 June 2019

Leaf area index (LAI) and fraction of photosynthetically active radiation (FPAR) absorbed by vegetation are two of the essential biophysical variables used in most global models of climate, hydrology, biogeochemistry, and ecology. Most LAI/FPAR produ...

  • Review
  • Open Access
2 Citations
3,415 Views
14 Pages

Advanced Cardiac Imaging in the Assessment of Aortic Stenosis

  • Kajetan Grodecki,
  • Mateusz Warniello,
  • Mateusz Spiewak and
  • Jacek Kwiecinski

Aortic stenosis is the most common form of valve disease in the Western world and a major healthcare burden. Although echocardiography remains the central modality for the diagnosis and assessment of aortic stenosis, recently, advanced cardiac imagin...

  • Review
  • Open Access
18 Citations
10,901 Views
11 Pages

Magnetic Resonance Imaging of Endometriosis: The Role of Advanced Techniques

  • Laura Alonzo,
  • Roberto Cannella,
  • Giuseppe Gullo,
  • Giulia Piombo,
  • Giuseppe Cicero,
  • Alessandra Lopez,
  • Valentina Billone,
  • Alessandra Andrisani,
  • Gaspare Cucinella and
  • Giuseppe Lo Re
  • + 1 author

28 September 2024

Endometriosis is a chronic inflammatory disease that affects about 10% of women, and it is characterized by the presence of endometrial tissue outside the uterine cavity. Associated symptoms are dyspareunia, chronic pelvic pain, and infertility. The...

  • Article
  • Open Access
23 Citations
5,132 Views
17 Pages

Advanced Fusion Imaging and Contrast-Enhanced Imaging (CT/MRI–CEUS) in Oncology

  • Vincent Schwarze,
  • Johannes Rübenthaler,
  • Constantin Marschner,
  • Matthias Philipp Fabritius,
  • Johannes Rueckel,
  • Nicola Fink,
  • Daniel Puhr-Westerheide,
  • Eva Gresser,
  • Matthias Frank Froelich and
  • Dirk-André Clevert
  • + 5 authors

30 September 2020

Fusion imaging depicts an innovative technique that facilitates combining assets and reducing restrictions of advanced ultrasound and cross-sectional imaging. The purpose of the present retrospective study was to evaluate the role of fusion imaging f...

  • Review
  • Open Access
2 Citations
2,345 Views
11 Pages

Hemorrhagic hydrocephalus is a common pathology in neonates with high mortality and morbidity. Current imaging approaches fail to capture the mechanisms behind its pathogenesis. Here, we discuss the processes underlying this pathology, the metabolic...

  • Viewpoint
  • Open Access
2 Citations
802 Views
4 Pages

There are several unique features of the concept of advanced intraoperative imaging modalities with CT (computed tomography), MRI (magnet resonance imaging) and DSA (digital substraction angiography) inaugurated in one operating tract. For the first...

  • Article
  • Open Access
19 Citations
4,209 Views
22 Pages

9 February 2022

A physical retrieval algorithm has been developed for deriving the layered precipitable water vapor (LPWs) product from infrared radiances of the Advanced Geosynchronous Radiation Imager (AGRI) onboard FengYun-4A (FY-4A), the first of the new generat...

  • Article
  • Open Access
3 Citations
1,064 Views
17 Pages

Epilepsy Surgery in Kazakhstan: Outcomes and the Role of Advanced Imaging

  • Dina Kalinina,
  • Nazira Bekenova,
  • Alimzhan Muxunov,
  • Zhassulan Utebekov,
  • Gaziz Kyrgyzbay,
  • Darkhan Kimadiev,
  • Guldana Zhumabaeva and
  • Antonio Sarria-Santamera

8 November 2025

Background and Objectives: Evidence on epilepsy surgery from Central Asia is limited, reflecting the real-world challenges of developing this service in low- and middle-income settings. We evaluated one-year seizure outcomes after resective surgery f...

  • Review
  • Open Access
83 Citations
8,967 Views
25 Pages

29 March 2021

Geo-Kompsat-2A (Geostationary-Korean Multi-Purpose SATtellite-2A, GK2A), a new generation of Korean geostationary meteorological satellite, carry state-of-the-art optical sensors with significantly higher radiometric, spectral, and spatial resolution...

  • Review
  • Open Access
7 Citations
7,154 Views
18 Pages

Advanced Microbubbles as a Multifunctional Platform Combining Imaging and Therapy

  • Xianwei Ni,
  • Jinmin Ye,
  • Liping Wang,
  • Shunlong Xu,
  • Chunpeng Zou,
  • Yan Yang and
  • Zhe Liu

21 November 2016

Microbubbles as traditional ultrasound contrast agents have seen tremendous developments and bio-applications in the past decades. Due to their outstanding performance, advanced microbubbles as a multifunctional platform combining both imaging and th...

  • Review
  • Open Access
7 Citations
8,601 Views
22 Pages

2 January 2025

Glioblastoma is the most common primary brain tumor in adult patients, and despite standard-of-care treatment, median survival has remained less than two years. Advances in our understanding of molecular mutations have led to changes in the diagnosti...

  • Article
  • Open Access
34 Citations
5,339 Views
16 Pages

27 April 2022

This paper proposes an image encryption scheme based on a discrete-time alternating quantum walk (AQW) and the advanced encryption standard (AES). We use quantum properties to improve the AES algorithm, which uses a keystream generator related to AQW...

  • Review
  • Open Access
3 Citations
3,765 Views
26 Pages

Applications of Advanced Imaging for Radiotherapy Planning and Response Assessment in the Central Nervous System

  • Liam S. P. Lawrence,
  • Rachel W. Chan,
  • Amit Singnurkar,
  • Jay Detsky,
  • Chris Heyn,
  • Pejman J. Maralani,
  • Hany Soliman,
  • Greg J. Stanisz,
  • Arjun Sahgal and
  • Angus Z. Lau

Background/Objectives: Radiotherapy for tumors of the central nervous system (CNS) could be improved by incorporating advanced imaging techniques into treatment planning and response assessment. The objective of this narrative review is to highlight...

  • Editorial
  • Open Access
507 Views
4 Pages

19 January 2026

On behalf of the Editors, we wish to express our sincere gratitude to all authors and reviewers who contributed to the success of this Special Issue, titled “Intraoperative Visualization Techniques and Advanced Imaging in Brain Tumors” [...]

  • Review
  • Open Access
9 Citations
10,464 Views
23 Pages

19 October 2016

Viruses must continuously evolve to hijack the host cell machinery in order to successfully replicate and orchestrate key interactions that support their persistence. The type-1 human immunodeficiency virus (HIV-1) is a prime example of viral persist...

  • Review
  • Open Access
17 Citations
6,045 Views
34 Pages

Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders

  • Emmanuel Ortega-Robles,
  • Benito de Celis Alonso,
  • Jessica Cantillo-Negrete,
  • Ruben I. Carino-Escobar and
  • Oscar Arias-Carrión

16 January 2025

Advanced magnetic resonance imaging (MRI) techniques are transforming the study of movement disorders by providing valuable insights into disease mechanisms. This narrative review presents a comprehensive overview of their applications in this field,...

  • Article
  • Open Access
21 Citations
4,481 Views
18 Pages

4 September 2020

The Chinese Fengyun–4A geostationary meteorological satellite was successfully launched on 11 December 2016, carrying an Advanced Geostationary Radiation Imager (AGRI) to provide the observations of visible, near infrared, and infrared bands wi...

  • Review
  • Open Access
3,472 Views
11 Pages

Illuminating the Shadows: Innovation in Advanced Imaging Techniques for Myeloma Precursor Conditions

  • Kara I. Cicero,
  • Rahul Banerjee,
  • Mary Kwok,
  • Danai Dima,
  • Andrew J. Portuguese,
  • Delphine Chen,
  • Majid Chalian and
  • Andrew J. Cowan

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM), the asymptomatic precursors to multiple myeloma, affect up to 5% of the population over the age of 40. Bone involvement, a myeloma-defining event, repres...

  • Review
  • Open Access
10 Citations
5,222 Views
34 Pages

19 October 2020

Intracellular micromanipulation assisted by robotic systems has valuable applications in biomedical research, such as genetic diagnosis and genome-editing tasks. However, current studies suffer from a low success rate and a large operation damage bec...

  • Review
  • Open Access
20 Citations
18,602 Views
24 Pages

Morphological and Advanced Imaging of Epilepsy: Beyond the Basics

  • Aikaterini Fitsiori,
  • Shivaprakash Basavanthaiah Hiremath,
  • José Boto,
  • Valentina Garibotto and
  • Maria Isabel Vargas

The etiology of epilepsy is variable and sometimes multifactorial. Clinical course and response to treatment largely depend on the precise etiology of the seizures. Along with the electroencephalogram (EEG), neuroimaging techniques, in particular, ma...

  • Review
  • Open Access
376 Views
36 Pages

Rare Earth-Doped Nanofluorescent Probes as Multifunctional Matrices for Advanced Biomedical Imaging

  • Jiayi Guo,
  • Hong-Bo Cui,
  • Dong Liu,
  • Chunzhi Li,
  • Guijian Guan and
  • Ming-Yong Han

Benefiting from tunable emission from ultraviolet to near-infrared windows, long luminescence lifetimes, and exceptional photostability, rare earth (RE)-doped nanomaterials overcome the limitations of conventional dyes and quantum dots, enabling deep...

  • Review
  • Open Access
6 Citations
6,315 Views
28 Pages

Transcatheter Device Therapy and the Integration of Advanced Imaging in Congenital Heart Disease

  • Abhay A. Divekar,
  • Yousef M. Arar,
  • Stephen Clark,
  • Animesh Tandon,
  • Thomas M. Zellers and
  • Surendranath R. Veeram Reddy

Transcatheter device intervention is now offered as first line therapy for many congenital heart defects (CHD) which were traditionally treated with cardiac surgery. While off-label use of devices is common and appropriate, a growing number of device...

  • Review
  • Open Access
29 Citations
12,739 Views
29 Pages

Prediction of Surgical Outcome in Advanced Ovarian Cancer by Imaging and Laparoscopy: A Narrative Review

  • Patrícia Pinto,
  • Andrea Burgetova,
  • David Cibula,
  • Ingfrid S. Haldorsen,
  • Tereza Indrielle-Kelly and
  • Daniela Fischerova

22 March 2023

Maximal-effort upfront or interval debulking surgery is the recommended approach for advanced-stage ovarian cancer. The role of diagnostic imaging is to provide a systematic and structured report on tumour dissemination with emphasis on key sites for...

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