Diagnostics, Volume 13, Issue 16
2023 August-2 - 104 articles
Cover Story: In medical mycology, the diagnosis of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients is crucial, since most clinical signs are not specific for invasive fungal infections. For microbiological diagnostics, different methods are available. In addition to the conventional culture-based approaches like staining and culture, non-culture-based methods can increase test sensitivity and improve the time-to-result. In this review, we evaluate and discuss the value of non-culture-based methods (galactomannan, (1→3)-β-D-glucan, Aspergillus PCR, new biomarker/targets) for diagnosing IPA in ICU patients. The combination of non-culture-based methods and the investigation of different respiratory specimens seem to be the best diagnostic pathway to detect IPA in ICU patients. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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