Mitochondrial ROS in Health and Disease: 2nd Edition

Dear Colleagues,

This Special Issue is the second edition of a previous Special Issue entitled “Mitochondrial ROS in Health and Disease” (https://www.mdpi.com/journal/biomolecules/special_issues/ET3M3W5F81).

Mitochondria are extremely membrane-rich organelles that play a central role in metabolism and key functions in cellular signaling and cell survival. Therefore, mitochondria are involved in various diseases and the aging process, which has provided a major impetus for extensive research on mitochondrial structure and function. In recent decades, many essential physiological roles of (mitochondrial) ROS have been (re)established, such as in the immune response, cell cycle regulation, and lifespan control.

Although the detrimental role of free radicals and other reactive species in organisms was the prevailing view for a long time, the health- and lifespan-promoting effects of ROS have emerged as an important topic, with some predominantly forgotten roots, e.g., the medicinal benefits of hydrogen peroxide dating more than a hundred years back. Similarly, many medicinally powerful biomolecules exert oxidative effects either directly or indirectly, including via mitochondrial ROS generation, e.g., paclitaxel and artemisinin.

This Special Issue focuses on current advances in mitochondrial-derived ROS and their effects on health and disease, particularly involving natural-based biomolecules. Both review manuscripts and original research articles are welcome to convey up-to-date insights and explore avenues for future research.

Dr. Frank Krause
Guest Editor

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