Stem and Progenitor Cells: Self-Renewal, Commitment and Differentiation – Conceptual and Practical Aspects

Dear Colleagues,

A Special Issue on “Stem and Progenitor Cells: Self-Renewal, Commitment and Differentiation – Conceptual and Practical Aspects” is being prepared for the journal Biomolecules. The fate of somatic stem cells is determined by a decision to proliferate without commitment or to commit and differentiate. Since both “symmetric” and “asymmetric” divisions are an option, the life span of a clone depends on the proliferative capacity of its initial stem cell and the extrinsic factors. This proliferative capacity of the initial stem cell, in fact, limits the total number of cells produced during the life span of a clone. The total number of cells produced during the proliferative history of a clone is in reality determined by the ratio between self-renewing and commitment/differentiation divisions. To harness stem cells and enable an appropriate ex vivo production of immature and mature cells, depending on the clinical demand, it is necessary to reveal the mechanisms of self-renewal, commitment, and differentiation. Original manuscript and reviews dealing with any aspect (physiology, biochemistry, cell biology, molecular biology, etc.) of somatic stem and progenitor cell self-renewal, commitment, and differentiation are welcome, as well as translational studies related to this issue.

Dr. Zoran Ivanovic
Guest Editor

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