Signaling Biomolecules in the Central Nervous System (CNS)—At the Nexus of Neuropsychiatric and Neurodegenerative Disorders

Dear Colleagues,

Signaling biomolecules are central to the transmission of information between cells and as such, are critical to the integrity of the organism and particularly important to the function of Central Nervous System (CNS). Consequently, they are also implicated in virtually all CNS disorders. Classical neurotransmitters, neuropeptides, neurotrophic factors and multiple peripherally released peptide hormones like insulin, ghrelin, irisin, or leptin all act as signaling biomolecules in CNS. Signaling biomolecules most often act as ligands for specific receptors, either membrane-bound or intracellular. However, single signaling biomolecule frequently has multiple known receptors of different functions, and even the same receptor can act differently in different cellular populations. Not surprisingly, a single signaling biomolecule is often known to play important roles in classically distinct ailments. Moreover, with improved diagnostics and advancement in clinical care, it’s becoming apparent that comorbidity in CNS disorders is the norm rather than the exception.

This special issue welcomes all work relating to signaling biomolecules in neuropsychiatric, neurodegenerative and other CNS disorders, focusing on their role in either pathophysiology or treatments. Especially original research papers investigating roles of specific molecules in comorbid disorders or role in interplay between different CNS disorders and review papers describing diverse roles and therapeutic potential of a specific molecule and their receptor system are encouraged for submission. More narrowly focused research papers are also welcome but they are encouraged to discuss their findings from potential importance to multiple disorders.

Prof. Dr. Irena Nalepa
Dr. Piotr Chmielarz
Prof. Dr. Mikko Airavaara
Guest Editors

Manuscript Submission Information

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