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  • Systematic Review
  • Open Access
745 Citations
210,950 Views
15 Pages

26 December 2023

The significant advancements in applying artificial intelligence (AI) to healthcare decision-making, medical diagnosis, and other domains have simultaneously raised concerns about the fairness and bias of AI systems. This is particularly critical in...

  • Article
  • Open Access
14 Citations
134,538 Views
33 Pages

On Hens, Eggs, Temperatures and CO2: Causal Links in Earth’s Atmosphere

  • Demetris Koutsoyiannis,
  • Christian Onof,
  • Zbigniew W. Kundzewicz and
  • Antonis Christofides

13 September 2023

The scientific and wider interest in the relationship between atmospheric temperature (T) and concentration of carbon dioxide ([CO2]) has been enormous. According to the commonly assumed causality link, increased [CO2] causes a rise in T. However, re...

  • Article
  • Open Access
5 Citations
81,622 Views
27 Pages

14 March 2024

Recent studies have provided evidence, based on analyses of instrumental measurements of the last seven decades, for a unidirectional, potentially causal link between temperature as the cause and carbon dioxide concentration ([CO2]) as the effect. In...

  • Article
  • Open Access
8 Citations
62,413 Views
11 Pages

Giftedness and Twice-Exceptionality in Children Suspected of ADHD or Specific Learning Disorders: A Retrospective Study

  • Sara Romano,
  • Dario Esposito,
  • Miriam Aricò,
  • Elena Arigliani,
  • Gioia Cavalli,
  • Miriam Vigliante,
  • Roberta Penge,
  • Carla Sogos,
  • Francesco Pisani and
  • Maria Romani

10 April 2024

The expression “twice-exceptionality” has been used to describe conditions in which giftedness and specific disorders coexist. Our study offers a retrospective analysis of clinical reports of gifted children evaluated for suspected specif...

  • Review
  • Open Access
15 Citations
41,018 Views
24 Pages

Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies

  • Muhammad Redza Fahmi Mod Razif,
  • Siok Yee Chan,
  • Yik-Ling Chew,
  • Masriana Hassan,
  • Shairyzah Ahmad Hisham,
  • Shamima Abdul Rahman,
  • Chun-Wai Mai,
  • Michelle Yee Mun Teo,
  • Phei Er Kee and
  • Kai Bin Liew
  • + 2 authors

25 October 2024

With approximately 18 million people affected by cancer in 2020 globally, scientists are exploring innovative approaches to develop effective treatments for various types of cancer. Traditional chemotherapy drugs, although effective against cancer ce...

  • Review
  • Open Access
38 Citations
34,606 Views
38 Pages

Challenges and Opportunities in the Implementation of AI in Manufacturing: A Bibliometric Analysis

  • Lorena Espina-Romero,
  • Humberto Gutiérrez Hurtado,
  • Doile Ríos Parra,
  • Rafael Alberto Vilchez Pirela,
  • Rosa Talavera-Aguirre and
  • Angélica Ochoa-Díaz

3 October 2024

This study explores the evolution and impact of research on the challenges and opportunities in the implementation of artificial intelligence (AI) in manufacturing between 2019 and August 2024. By addressing the growing integration of AI technologies...

  • Review
  • Open Access
55 Citations
32,405 Views
24 Pages

Evolving Paradigms of Recombinant Protein Production in Pharmaceutical Industry: A Rigorous Review

  • Achuth Jayakrishnan,
  • Wan Rosalina Wan Rosli,
  • Ahmad Rashidi Mohd Tahir,
  • Fashli Syafiq Abd Razak,
  • Phei Er Kee,
  • Hui Suan Ng,
  • Yik-Ling Chew,
  • Siew-Keah Lee,
  • Mahenthiran Ramasamy and
  • Kai Bin Liew
  • + 1 author

31 January 2024

Many beneficial proteins have limited natural availability, which often restricts their supply and thereby reduces their potential for therapeutic or industrial usage. The advent of recombinant DNA (rDNA) technology enables the utilization of differe...

  • Article
  • Open Access
66 Citations
31,952 Views
22 Pages

LSTM–Transformer-Based Robust Hybrid Deep Learning Model for Financial Time Series Forecasting

  • Md R. Kabir,
  • Dipayan Bhadra,
  • Moinul Ridoy and
  • Mariofanna Milanova

10 January 2025

The inherent challenges of financial time series forecasting demand advanced modeling techniques for reliable predictions. Effective financial time series forecasting is crucial for financial risk management and the formulation of investment decision...

  • Review
  • Open Access
62 Citations
25,552 Views
26 Pages

15 December 2023

In recent years, generative transformers have become increasingly prevalent in the field of artificial intelligence, especially within the scope of natural language processing. This paper provides a comprehensive overview of these models, beginning w...

  • Review
  • Open Access
61 Citations
23,111 Views
16 Pages

30 October 2023

Blockchain offers a cutting-edge solution for storing medical data, carrying out medical transactions, and establishing trust for medical data integration and exchange in a decentralized open healthcare network setting. While blockchain in healthcare...

  • Review
  • Open Access
40 Citations
18,411 Views
37 Pages

9 April 2025

Microbial enzymes have revolutionised the textile industry by replacing harmful chemicals with eco-friendly alternatives, enhancing processes such as desizing, scouring, dyeing, finishing, and promoting water conservation while reducing pollution. Th...

  • Review
  • Open Access
8 Citations
13,234 Views
23 Pages

Cassia alata and Its Phytochemicals: A Promising Natural Strategy in Wound Recovery

  • Jing-Wen Keng,
  • Sue-Kei Lee,
  • Sze-Huey Sang,
  • Kai-Bin Liew,
  • Swee-Sen Teo,
  • Wan Mastura Shaik Mohamed Mossadeq,
  • Sek-Chuen Chow,
  • Gabriel Akyirem Akowuah,
  • Siew-Keah Lee and
  • Yik-Ling Chew
  • + 1 author

3 June 2024

Cassia alata, a traditional herb with a global presence, is renowned for its anti-inflammatory, antibacterial, and antifungal properties, making it a go-to remedy for skin ailments. While it has demonstrated wound healing capabilities in both in vitr...

  • Article
  • Open Access
9 Citations
12,396 Views
15 Pages

15 August 2024

The well-known Gaussian plume model has proven to be very useful in simulating the atmospheric dispersion of air pollutants (both gaseous and particulates). Nevertheless, the nature of the model presents problems in the actual computation of concentr...

  • Article
  • Open Access
3 Citations
12,207 Views
17 Pages

Effects of a Ready-to-Drink Hydrolyzed Collagen from Sea Bass Skin on Skin Health: A 30-Day Clinical Trial

  • Suttiwan Wunnoo,
  • Chanawee Jakkawanpitak,
  • Rajeev Shankar Rajagopal and
  • Thanaporn Amnuaikit

1 October 2025

Food waste from fish processing contributes significantly to environmental pollution, and fish skin is often discarded despite being a rich collagen source. This study evaluated the efficacy and consumer satisfaction of a ready-to-drink collagen supp...

  • Article
  • Open Access
15 Citations
11,775 Views
22 Pages

10 April 2025

Eye-gaze writing technology holds significant promise but faces several limitations. Existing eye-gaze-based systems often suffer from slow performance, particularly under challenging conditions such as low-light environments, user fatigue, or excess...

  • Review
  • Open Access
8 Citations
11,587 Views
13 Pages

1 March 2024

The African Growth Opportunity Act (AGOA) has been a crucial trade and development initiative, offering preferential access to qualified Sub-Saharan African (SSA) countries to the United States market since its enactment in 2000. This paper presents...

  • Review
  • Open Access
10 Citations
11,346 Views
16 Pages

Recent Research on Linseed Oil Use in Wood Protection—A Review

  • Dace Cirule,
  • Ingeborga Andersone,
  • Edgars Kuka and
  • Bruno Andersons

5 September 2024

Although linseed oil (LO) has been used in wood protection for centuries, research continues to develop new and more effective formulations and treatment approaches. In the future, growing interest in LO use could be expected due to its cost and envi...

  • Review
  • Open Access
20 Citations
11,132 Views
21 Pages

4 February 2024

Petrochemical feedstocks are experiencing a fast growth in demand, which will further expand their market in the coming years. This is due to an increase in the demand for petrochemical-based materials that are used in households, hospitals, transpor...

  • Review
  • Open Access
14 Citations
11,059 Views
30 Pages

Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review

  • Emeka Joshua Iweala,
  • Oluwapelumi Eniola Adurosakin,
  • Ugochukwu Innocent,
  • Conrad A. Omonhinmin,
  • Omoremime Elizabeth Dania and
  • Eziuche Amadike Ugbogu

13 June 2024

Aging is a complex biological and physiological change that leads to a loss of function in all living organisms. Although the mechanism behind the aging process is still largely unknown, scientific studies have shown that oxidative stress and age-rel...

  • Review
  • Open Access
19 Citations
10,415 Views
17 Pages

An Overview on Spheroid and Organoid Models in Applied Studies

  • Zorislava Živković and
  • Teuta Opačak-Bernardi

4 March 2025

From its inception, cell culture has been a great scientific tool for researchers in many diverse fields. The advancement from monolayer 2D cultures into three-dimensional cellular systems enabled a better experimental tool, as the 3D culture mimics...

  • Review
  • Open Access
12 Citations
10,084 Views
31 Pages

Module-Lattice-Based Key-Encapsulation Mechanism Performance Measurements

  • Naya Nagy,
  • Sarah Alnemer,
  • Lama Mohammed Alshuhail,
  • Haifa Alobiad,
  • Tala Almulla,
  • Fatima Ahmed Alrumaihi,
  • Najd Ghadra and
  • Marius Nagy

1 July 2025

Key exchange mechanisms are foundational to secure communication, yet traditional methods face challenges from quantum computing. The Module-Lattice-Based Key-Encapsulation Mechanism (ML-KEM) is a post-quantum cryptographic key exchange protocol with...

  • Review
  • Open Access
13 Citations
9,865 Views
22 Pages

Pesticides in the Environment: Benefits, Harms, and Detection Methods

  • Francis Xavier D. Verdadero,
  • Alfred Z. Agarap,
  • Czarina Nicole E. Macatingrao,
  • Isagani A. Ordonez,
  • Lady Edlenill J. Tavu,
  • David Pires and
  • Mark Angelo O. Balendres

21 November 2025

Pesticides play a critical role in food production by enhancing crop yields and protecting against pests and pathogens, such as insects, bacteria, fungi, and weeds. However, their extensive use raises significant environmental concerns. The paper rev...

  • Article
  • Open Access
29 Citations
9,645 Views
12 Pages

2 April 2024

Audio classification using deep learning models, which is essential for applications like voice assistants and music analysis, faces challenges when deployed on edge devices due to their limited computational resources and memory. Achieving a balance...

  • Review
  • Open Access
6 Citations
9,507 Views
16 Pages

Understanding Fatigue: A Psychological Framework for Health and Performance

  • Andrew M. Lane,
  • Dominic Micklewright and
  • Carla Meijen

6 November 2025

Fatigue is a multidimensional phenomenon with profound implications for performance, health, and wellbeing. Its complexity means that no single discipline can adequately explain its causes or management, highlighting the need for integrative approach...

  • Review
  • Open Access
8 Citations
8,816 Views
30 Pages

1 July 2025

Wilson’s disease is a rare autosomal recessive disorder of copper metabolism characterized by excessive copper accumulation in the liver, brain, and other tissues. This paper provides an overview of the primary pharmacological agents used in it...

  • Review
  • Open Access
1 Citations
8,793 Views
13 Pages

Exercise as Medicine: Tackling Chronic Pain and Depression to Boost Quality of Life—A Narrative Review

  • William J. Hanney,
  • Abigail W. Anderson,
  • Morey J. Kolber,
  • Violette Gibbs and
  • William J. Hanney

15 January 2025

Depression and chronic pain are prevalent and often co-occurring conditions that pose substantial treatment challenges and economic burdens in the developed world. Research suggests that depression and chronic pain share overlapping pathways, particu...

  • Review
  • Open Access
21 Citations
8,416 Views
27 Pages

A Review of the State of the Art for the Internet of Medical Things

  • Peter Matthew,
  • Sarah Mchale,
  • Xutao Deng,
  • Ghada Nakhla,
  • Marcello Trovati,
  • Nonso Nnamoko,
  • Ella Pereira,
  • Huaizhong Zhang and
  • Mohsin Raza

24 March 2025

The technological developments in the Internet of Things (IoT), data science, artificial intelligence, wearable sensors, remote monitoring, decision support systems, fog, and edge systems have transformed digital healthcare. Especially after the pand...

  • Article
  • Open Access
6 Citations
8,265 Views
18 Pages

2 April 2024

Mental illnesses, such as clinical depression, have taken an unprecedented toll on society and the economy on a global scale. The relationship between stress management and mental health decline is of utmost significance, especially as most avenues o...

  • Concept Paper
  • Open Access
32 Citations
8,242 Views
16 Pages

Digital Twins in Manufacturing: A RAMI 4.0 Compliant Concept

  • Martin Lindner,
  • Lukas Bank,
  • Johannes Schilp and
  • Matthias Weigold

10 October 2023

Digital twins are among the technologies that are considered to have high potential. At the same time, there is no uniform understanding of what this technology means. Definitions are used across disciplinary boundaries, resulting in a multitude of d...

  • Article
  • Open Access
19 Citations
8,103 Views
21 Pages

2 August 2024

This study investigates the potential health risks associated with consuming mussels (Mytilus galloprovincialis Lamarck, 1819) from the Romanian Black Sea coast between 2001 and 2023. The research focuses on heavy metal (copper, cadmium, lead, nickel...

  • Article
  • Open Access
6 Citations
8,016 Views
21 Pages

Implementing Person-Centred Lean Six Sigma to Transform Dermatology Waiting Lists: A Case Study from a Major Teaching Hospital in Dublin, Ireland

  • Aileen Igoe,
  • Seán Paul Teeling,
  • Orla McFeely,
  • Michelle McGuirk,
  • Siobhan Manning,
  • Vanessa Kelly,
  • Heather Coetzee,
  • Úna Cunningham,
  • Karen Connolly and
  • Patsy Lenane

4 November 2024

The study site, a major teaching hospital in Dublin, Ireland, addressed significant challenges within its dermatology service through a comprehensive improvement initiative using a person-centred Lean Six Sigma methodology. Initially, the hospital&rs...

  • Article
  • Open Access
12 Citations
7,872 Views
16 Pages

The Perceptions of Generation Z University Students about Their Futures: A Qualitative Study

  • Gül Dikeç,
  • Simge Öztürk,
  • Neslihan Taşbaşı,
  • Damla Figenergül and
  • Bilal Buğrahan Güler

8 December 2023

This study explored the future-oriented perceptions of Generation Z students in a foundation university. This study was conducted using qualitative research and a phenomenological design. The study sample consisted of 11 university students over the...

  • Article
  • Open Access
4 Citations
7,588 Views
21 Pages

26 September 2023

The aim of this research is to present the effects of acupuncture treatment on morning blood glucose level (BGL) in type 2 diabetes mellitus (T2DM) patients, and to describe them by a predictive model. The morning BGL is measured after overnight fast...

  • Article
  • Open Access
11 Citations
7,461 Views
19 Pages

Deep-Learning-Based Real-Time Visual Pollution Detection in Urban and Textile Environments

  • Md Fahim Shahoriar Titu,
  • Abdul Aziz Chowdhury,
  • S. M. Rezwanul Haque and
  • Riasat Khan

11 January 2024

The environmental physiognomy of an area can significantly diminish its aesthetic appeal, rendering it susceptible to visual pollution, the unbeaten scourge of modern urbanization. In this study, we propose using a deep learning network and a robotic...

  • Review
  • Open Access
1 Citations
7,457 Views
14 Pages

Characterization of All Allotropes of Phosphorus

  • John T. Walters,
  • Meijuan Cao,
  • Yuki Lam,
  • Gregory R. Schwenk and
  • Hai-Feng Ji

9 September 2025

Recent advancements in carbon nanotubes and graphene have driven significant research into other low-dimensional materials, with phosphorus-based materials emerging as a notable area of interest. Phosphorus nanowires and thin sheets show promise for...

  • Article
  • Open Access
2 Citations
7,298 Views
13 Pages

3 June 2024

During the COVID-19 pandemic, physical activity was significantly decreased in all age groups. The purpose of this study is to investigate children’s motor skills by administering an adapted physical activity program for the development of coor...

  • Review
  • Open Access
3 Citations
7,083 Views
13 Pages

Aberrant Number of Vessels in the Umbilical Cord: What Do We Know?

  • Valentino Remorgida,
  • Anthony Nicosia,
  • Livio Leo,
  • Libera Troìa and
  • Alessandro Libretti

19 October 2024

The umbilical cord, comprising three vital blood vessels, serves as the lifeline between mother and fetus. Prenatal care emphasizes detailed ultrasound examinations of the umbilical cord and postnatal inspections of the placenta and cord to preemptiv...

  • Article
  • Open Access
5 Citations
6,948 Views
11 Pages

2 May 2025

This study investigates the influence of varying nitrogen-to-phosphorus (N:P) ratios on the growth, nutritional composition, and nutrient removal efficiency of Wolffia globosa under controlled laboratory conditions. Six treatments with N:P ratios of...

  • Review
  • Open Access
15 Citations
6,822 Views
40 Pages

Advancements of Biohydrogen Production Based on Anaerobic Digestion: Technologies, Substrates, and Future Prospects

  • Rossana Parra,
  • Cristhian Chicaiza-Ortiz,
  • Robinson J. Herrera-Feijoo,
  • Diana Victoria Arellano-Yasaca,
  • Lien-Chieh Lee,
  • Roberto Xavier Supe-Tulcan and
  • Jaime Marti-Herrero

29 April 2025

Population growth has significantly increased energy and resource demands, driving research toward cost-effective technologies that repurpose waste into alternative energy forms such as biohydrogen. This review aims to comprehensively evaluate biohyd...

  • Article
  • Open Access
13 Citations
6,429 Views
23 Pages

Application of Coffee Silverskin Cellulose/Polyacrylamide Gel Polymer Electrolytes for Rechargeable Zinc-Ion Batteries

  • Vorrada Loryuenyong,
  • Jessada Khamsawat,
  • Panuwit Danwong,
  • Achanai Buasri and
  • Prasit Pattananuwat

2 September 2024

Rechargeable zinc-ion batteries (ZIBs) have grown in popularity due to their low cost and the abundance of resources. However, there has been little research into the development of gel polymer electrolytes (GPEs) for high voltage and capacity ZIBs....

  • Systematic Review
  • Open Access
5 Citations
6,345 Views
31 Pages

18 January 2024

The Bryonia genus (Cucurbitaceae) is divided into 13 plants considered medicinal species with a significant pharmacological value fortreating as well as preventing various ailments. The current systematic review aims to present useful and updated fin...

  • Article
  • Open Access
4 Citations
6,052 Views
23 Pages

Opportunities and Challenges of Industries 4.0 and 5.0 in Latin America

  • Germán D. Rueda-Carvajal,
  • Oscar A. Tobar-Rosero,
  • Gabriel J. Sánchez-Zuluaga,
  • John E. Candelo-Becerra and
  • Héctor Andrés Flórez-Celis

18 May 2025

The Fourth Industrial Revolution is transforming global industries. However, Latin America faces significant challenges in adopting these technologies. Particularly, small- and medium-sized enterprises constitute the backbone of the economy in the re...

  • Review
  • Open Access
6 Citations
5,943 Views
11 Pages

2 August 2024

Hormone replacement therapy (HRT) is a treatment for acute climacteric syndrome, with the best effectivity. It also prevents bone loss and fractures. Ischemic heart disease prevention and cognitive function improvement have been observed with HRT, on...

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